Formation of Pharmaceutical Cocrystals and Control of Drug Solubility using Fatty Acids

Abstract

Cocrystals have attracted attention as a promising approach to enhance drug concentration in water. Our study explores formation of pharmaceutical cocrystals using fatty acids as a safe medium and their role in controlling drug concentration. In this study, calculations of the Gibbs energy change and experiments on cocrystal formation revealed that the ability of solvents to form cocrystals is attributed to the stability of the drug and coformer in the solvent.