Alteration of Cation Metabolism: a Prototype Etiological Model of Hypertension
1994 年 17 巻 3 号 p. 149-155
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1994 年 17 巻 3 号 p. 149-155
Essential hypertension (EH) is a progressive rise in blood pressure (BP) with age for which there is no obvious cause. Its unique clinical marker is the high BP itself. No other abnormality appears to be common to all hypertensive patients. Our understanding of the mechanisms that keep BP high has improved considerably and a number of clues to potential causes have been found. High BP arises from the interactions between an organism's attributes and environmental factors. The former may include abnormal transmembrane ion transport systems. There are a number of hypotheses postulating how abnormal sodium or calcium metabolism causes increased systemic vascular resistance through altered vaso-active responses, structural changes in the vasculature, or both. (Hypertens Res 1994; 17: 149-155)
