2003 Volume 123 Issue 3 Pages 209-212
Manipulation and analytical method for single DNA molecules has been under development. The manipulation uses the transformation of DNA to globular state. Using the reverse transformation, single DNA molecules can be fixed in stretched mode for characterization. Fragments of the stretched DNA molecule can be cut and amplified by PCR (Polymerase Chain Reaction) using droplets as a container of single molecules and chemical agent. These techniques can be incorporated for micro-total analysis system.
The transactions of the Institute of Electrical Engineers of Japan.A
The Journal of the Institute of Electrical Engineers of Japan