A Hemoglobin and Volume Measurement Sensor for Point of Care Testing Analyzer Using MEMS Process

Abstract

To develop a miniature complete blood count (CBC) analyzer for point-of-care testing (POCT), a disposable MEMS hemoglobin and volume measurement sensor was discussed. The light emitting diode (LED) and photo detector were arranged in the mainframe to allow repeated use. However, the fluidic path, optical cell, and optical waveguides with quartz optical fiber (φ250μm) were arranged in the MEMS disposable chip. The sensors were fabricated successfully using an SU-8 photolithography process. The proposed volume measurement sensor was shown to detect the presence of sample liquid at two locations with a single light source and photo detector. The hemoglobin concentration sensor provided good linearity in the range of normal physiological values to decreased values requiring immediate care. The new MEMS hemoglobin and volume measurement sensor demonstrated potential application as a miniature CBC analyzer.