IEEJ Transactions on Sensors and Micromachines
Online ISSN : 1347-5525
Print ISSN : 1341-8939
Special Issue Paper
Development of a Body-on-a-Chip Using 3-D Microstructuring Technique
Yoshiki KatoYoshikazu HiraiKen-ichiro KameiToshiyuki TsuchiyaOsamu Tabata
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2016 Volume 136 Issue 6 Pages 229-236

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Abstract

In vitro cell-based assay with human cells is getting attention since the accuracy of preclinical predictions of drug responses should be improved to reducing costly failures in clinical trials. In order to generate reliable predictions, we present a micro-engineered biomimetic systems “Body-on-a-Chip”, to investigate the effects of drugs/metabolites on various organs by assembling a closed-loop medium circulation system on one microfluidic device. For three-dimensional (3-D) polymeric device fabrication, an advanced 3-D lithography with the process optimization method is applied to improve the current soft-lithography technique. Our Body-on-a-Chip is successfully applied to evaluate the effect of an anti-cancer drug (doxorubicin) on cell survival of human heart and liver cells.

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© 2016 by the Institute of Electrical Engineers of Japan
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