Integration of Gold- Nanofève -Based-SERS Active Nanostructure and Microfluidic Devices

Abstract

Surface-enhanced Raman scattering (SERS) is expected to be applied to real-time measurements in bioanalysis and environmental analysis because of its high sensitivity, label-free measurements, and suitability for long-term measurements. We are focusing on gold nanofève (GNF)-SERS structure deposited on a boehmite substrate because it is capable to have high-sensitivity and high-resolution measurements in a wide area. GNF-SERS-active patterns with improved adhesion by magnetron sputtering process were fabricated to integrate a microfluidic system. To evaluate the performance of the system, 4, 4'-Bypiridine (4bpy) was used for SERS measurement in the microchannel. This study shows that our microfluidic systems with the GNF-SERS active patterned area have the adequate potential for application and development in environmental analysis.