IEEJ Transactions on Sensors and Micromachines
Online ISSN : 1347-5525
Print ISSN : 1341-8939
ISSN-L : 1341-8939
Electrochemical array (ECA) as an integrated multi-electrode DNA sensor
Hiroyoshi MiyaharaKenichi YamashitaMakoto TakagiHiroki KondoShigeori Takenaka
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2001 Volume 121 Issue 4 Pages 187-191

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Abstract
An electrochemical array, ECA, for DNA analysis was designed and constructed as a microarray for the next generation by integrating DNA sensing multiple electrodes. Probe DNAs were immobilized on 25 electrodes of an ECA chip and allowed to detect the target DNA with ferrocenylnaphthalene diimide (FND) as an indicator. As an application example of this system for single nucleotide polymorphisms (SNPs) analysis, a DNA mismatch on the cancer repression gene p53 was successfully analyzed with 88% precision.
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© The Institute of Electrical Engineers of Japan
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