International Heart Journal
Online ISSN : 1349-3299
Print ISSN : 1349-2365
ISSN-L : 1349-2365
Clinical Studies
General Anesthesia or Conscious Sedation for Transfemoral Aortic Valve Replacement with the SAPIEN 3 Transcatheter Heart Valve
Franz-Josef NeumannSimon RedwoodMohamed Abdel-WahabThierry LefèvreDerk FrankHélène EltchaninoffChristophe CaussinPieter R. StellaTomas HovorkaHelmut BaumgartnerGiuseppe TarantiniOlaf WendlerHendrik Treedeon behalf of SOURCE 3 Investigators
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2020 Volume 61 Issue 4 Pages 713-719

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Abstract

Differences in the benefits of conscious sedation (CS) and general anesthesia (GA) during transfemoral aortic valve implantation (TAVI) are unclear.

We aimed to assess differences in procedural and clinical outcomes based on the type of anesthesia received during TAVI.

We analyzed SOURCE 3 Registry data for patients who received the SAPIEN 3 valve by type of anesthesia used during TAVI.

Of the 1694 TAVI patients, 1027 received CS and 667 received GA. Patients were similar at baseline (81.5 years; Society of Thoracic Surgeons risk score 7.0). Compared with the GA group, the CS group had fewer intra-procedural transesophageal echocardiography (TEE) and post implantation dilatations performed, and less contrast medium was used. The CS group had significantly less kidney injury at 7 days post-procedure than the GA group (0.4% versus 1.5%, P = 0.014). Moderate paravalvular leaks (PVL) occurred more frequently in the CS group versus the GA group (2.2% versus 0.8%; P = 0.041). No severe PVL were reported. Median total hospital length of stay (LOS) after TAVI was 10 days in the CS group and 11 days in the GS group. At 30 days, all-cause death was 2.1% in CS and 1.7% in GS (P = 0.47), and myocardial infarction was 0.2% in CS and 0.1% in GS (P = 0.83).

Our analyses found no significant major outcome differences between CS and GA during TAVI.

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© 2020 by the International Heart Journal Association
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