抄録
Ventricular arrhythmias accompanied by vagal or sympathetic hyperactivity occur frequently in the acute stage of myocardial infarction. The experiments were designed to study the influence of vagal or sympathetic activity on the incidence of ventricular arrhythmias after coronary occlusion. A right vagus or a left sympathetic nerve was electrically stimulated in anesthetized dogs before and after coronary occlusion while the electrocardiogram was monitored continuously. Sympathetic stimulation was found to enhance the frequency of ventricular arrhythmias very slightly after coronary occlusion. Vagal stimulation, in 4 out of 7 dogs, consistently elicited runs of ventricular tachycardia, the rate of which was slower than the sinus rate. On the other hand, sporadic ventricular extrasystoles coupled to the sinus beat were prevented by the suppression of the sinus rate. Ventricular fibrillation was not produced by either sympathetic or vagal stimulation.
