抄録
Quantitative analysis of spontaneous movement revealed that SHR moved somewhat more than WK during the day time, when they were exposed to environmental stimuli more frequently than at night, and that SHR showed a greater increase in movement than WK when exposed to hypoxia.
Consequently, SHR appeared to be more reactive to environmental alteration. Diurnal variation of the spontaneous movement became irregular in stroke-prone SHR (SHRSP) when they showed some alterations in the character some time before they died with cerebrovascular lesions. The transient episode of repetitive movement possibly related to hypertensive encephalopathy was detected by continuous recording of spontaneous movement. Saltloading accelerated the appearance of these abnormal behaviors in SHRSP.
Raphe-lesioned SHR showed a hyperkinetic or hyperresponsive state which appeared to be affected by the alteration of brain serotonin level, and the possible relationship between brain monoamine metabolism and the hyperreactive character in SHR was discussed.
