A Preliminary Attempt of Selecting Normotensive Atherogenic Rats (NAR)

抄録

In the F₂ generation obtained by the cross breeding between normotensiveVol.19 No.4 SPONTANEOUSLY HYPERTENSIVE RAT 629male WK and hypertensive female substrain of SHRSP (A₁-sb) which had low and high susceptibility to arterial fat deposition, respectively, ring-like fat deposits in the cerebral and mesenteric arteries were observed in high percentage (around 50%). These rats were mostly normotensive (under 150mmHg) and there were no significant differences in blood pressure and serum cholesterol level between rats with and without fat deposition.
These experimental facts suggested that some genetic factors for vascular atherogenesis indifferent to hypertensive genetic factors might be involved in A₁-sb strain of SHRSP and there seems to be a probability for extablishing normotensive atherogenic rats (NAR) by the selective inbreeding of rats from parents which have a high susceptibility to fat deposition and are normotensive. That is, after the development of ring-like fat deposits is confirmed in the cerebral and mesenteric arteries in "normotensive" rats by the BCSS method or by the extirpation of mesenteric arteries, the inbreeding of their descendants is expected to enable us to establish in the near future the new strain which develops fat depositions in cerebral and mesenteric arteries without exception and as yet are normotensive.