An Essential Difference between Stroke-prone SHR (SHRSP) and Stroke-resistant SHR (SHRSR)

Quantitative Evidence Obtained by Yamori's Preparation II

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The susceptibility to cerebrovascular fat deposition in prehypertensive SHRSP and SHRSR, with or without unilateral carotid artery ligation, was investigated.
Although no fat deposits were observed in either SHRSP or SHRSR without the carotid ligation, the operated group of SHRSP revealed a significantly higher susceptibility to cerebrovascular fat deposition than the operated SHRSR, qualitatively and quantitatively.
Cerebrovascular fat deposition was regarded as a good indicator for the detection of increased cerebrovascular permeability based on many experimental facts (Yamori et al: Jap Circulat J 39: 601, 1975). Thus, the higher susceptibility to cerebrovascular atherogenesis in prehypertensive SHRSP in comparison with SHRSR suggested that cerebrovascular wall of SHRSP had generically a greater susceptibility to vascular permeability which causes arterionecrosis followed by cerebral breeding or cerebral infarction.
The present study first substantiated a genetical difference, i.e., qualitative and quantitative in vulnerability to cerebrovascular permeability, apart from the heredity of severe hypertension in SHRSP. In addition, the result also suggested the osmotic fragility of erythrocyte membrane might be related to this vulnerability of cerebral arteries and a promising and practical approach for the prescience of cerebrovascular diseases.