Effects of Morphine and Pethidine on Coronary Vascular Resistance, Blood Pressure, and Myocardial Infarction-Induced Cardiac Arrhythmias

Kamlesh Kumar PANT; Vinod Kumar VERMA; Nisha MISHRA; Narendra SINGH; Jagdish Narain SINHA; Krishna Prasad BHARGAVA

doi:10.1536/ihj.24.127

Kamlesh Kumar PANT, Vinod Kumar VERMA, Nisha MISHRA, Narendra SINGH, Jagdish Narain SINHA, Krishna Prasad BHARGAVA

著者情報

キーワード: Morphine, Pethidine, Coronary vascular resistance, Cardiac arrhythmia

ジャーナルフリー

1983 年 24 巻 1 号 p. 127-133

DOI https://doi.org/10.1536/ihj.24.127

詳細

抄録

In the present study, the effects of morphine and pethidine on coronary vessel resistance (CPP), blood pressure (BP), and experimental myocardial infarction-induced cardiac arrhythmia were investigated. Both morphine and pethidine induced a fall in CPP and BP and inhibited the cardiac arrhythmia. The morphine effects on CPP and BP were largely blocked by mepyramine. The effects of pethidine, on the other hand, were not blocked by mepyramine, propranolol, or atropine. An interesting dose dependent inhibition of cardiac arrhythmia was observed with pethidine.

責任著者(Corresponding author)

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