The Effects of Several Anti-hypertensive Drugs on Vascular Changes to Organs on M-SHRSP and SHRSP
1990 年 31 巻 4 号 p. 544
詳細
1990 年 31 巻 4 号 p. 544
Captopril, SQ 29852, hydralazine or a combination therapy was administered to 11-week-old male M-SHRSP and 20- to 25-week-old male SHRSP all of which evidenced angionecrosis in verious organs. Blood pressures for captopril or SQ 29852 or hydralazine groups slightly lowered to about 220mmHg, and those of combination therapy groups decreased within normal range. In captopril, SQ 29852 and combination group, fibrinoid substances of blood vessels were absorbed and disappeared, and vacuoles were found in vessel wall, and smooth muscle cells proliferated and, then, blood vessels repaired. These latter effects were not seen in the rats given hydralazine.
