Japanese Heart Journal
Online ISSN : 1348-673X
Print ISSN : 0021-4868
ISSN-L : 0021-4868
Effects of a New Antiarrhythmic Drug, SD-3212, on Canine Ventricular Arrhythmia Models
Akira HIRASAWAAkihiko HARUNOTakushi MATSUZAKIKeitaro HASHIMOTO
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1992 年 33 巻 6 号 p. 851-861

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The antiarrhythmic effects of a new antiarrhythmic agent, SD-3212, (-)-(S)-3, 4-Dihydro-2-[5-methoxy-2-[3-[N-methyl-N-[2-[(3, 4-methylene dioxy)phenoxy]ethyl]amino]propoxy]phenyl]-4-methyl-3-oxo-2H-1, 4-benzothiazine hydrogen fumarate, were investigated using canine models of ventricular arrhythmias, i.e. spontaneously occurring digitalis-, two-stage coronary ligation- and adrenaline-induced arrhythmias. SD-3212 suppressed adrenaline-induced arrhythmia and showed some antiarrhythmic effect on digitalis- and 48hr coronary ligation-arrhythmias. These results indicate that SD-3212 has antiarrhythmic effects common among class IV antiarrhythmic drugs and also has additional efficacy common among class I antiarrhythmic drugs, thus when considering the level of experimental arrhythmias it somewhat resembles propafenone. It may therefore become a clinically useful antiarrhythmic drug among typical class I or class IV antiarrhythmic drugs.
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© by International Heart Journal Association
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