ICMR2017 AKITA I Originals
Synthesis and Properties of Hyperbranched Poly(L-lactide)s Having Glutamic Acid Terminals
2018 年 23 巻 1 号 p. 53-58
詳細
2018 年 23 巻 1 号 p. 53-58
The introduction of zwitterionic groups improves hydrophilicity and antithrombogenicity of the target materials. In this study, chemical modification of hydroxy terminals of hyperbranched poly(Llactide)s (AB2 PLLAs) by glutamic acid (Glu) was performed to introduce zwitterionic hydrophilic groups. The structures of AB2 PLLAs and Glu-esterified AB2 PLLAs (AB2 PLLA-Glus) were confirmed by NMR measurements. The contact angles of AB2 PLLA-Glus were lower than those of AB2 PLLA due to the influence of large number of Glu terminals. Microphase-separated morphology was observed on the film of AB2 PLLA-Glu, which is a promising surface for anti-platelet adhesion.
