INFLUENCE OF ZINC, VITAMIN B12 AND GLUTATHIONE ON THE LIVER OF RATS EXPOSED TO CARBON TETRACHLORIDE

Abstract

Protective effects of three agents viz. metallic zinc, glutathione and vitamin B12 have been tested against carbon tetrachloride induced hepatic injury in rat Rattus rattus albino taking few biochemical parameters. Induced protein synthesis has been correlated with increased transcriptional activity of DNA. Data on carbohydrates suggest the reversal of enzyme and coenzyme activities. However, the manner in which these drugs might have caused lipotropic effects remains elusive. Nevertheless, stabilization of biomembranes by zinc, lipid soluble character of vitamins and importance of glutathione as a SH product have been discussed.