MECHANISM OF HAEMOLYSIS CAUSED BY VARIOUS SUBSTANCES

I. COMPARISON OF HAEMOLYTIC CURVES BY VARIOUS SUBSTANCES

Abstract

For the purpose of understanding the mechansim of haemolysis caused by various substances, the comparison of haemolytic action of various substances was carried out from the relation between the concentrations of substances and the incubation time with red blood cell.
The phenomenon of haemolysis caused by various substances could be divided into two groups. The first group is haemolysis produced by the substances such as surface detergent, alcohols, urea and tauroglycocholate, and the difference between the concentra-tion producing complete haemolysis and that causing scarce haemolysis is very narrow. Haemolysis of the second group shows a very wide range of concentration, and is pro-duced by metals and organometallic compounds. The difference of mechanism of haemolysis caused by thosetwo groups was discussed.
The comparison of haemolytic action by chemical compounds having similarstructure was also studied.