THE EFFECT OF QUARTZ PARTICLES ON THE INCORPORATION OF C¹⁴-AMINO ACID AND C¹⁴-PALMITIC ACID INTO THE CELLS

Abstract

The effect of quartz particles on the incorporation of C¹⁴-leucine and C¹⁴-glycine into rat intraperitoneal macrophage protein was studied. The incorporations of C¹⁴- leucine and C¹⁴-glycine were inhibited very rapidly and remarkably by alkali-treated quartz particles, but not by ground quartz particles. And the incorporation of C¹⁴- palmitic acid into cell lipid was also strongly inhibited by alkali-treated quartz parti-cles. The lactic acid production and the succinoxidase activity of the cells did not decrease by the addition of quartz particles under above experimental condition. So, it was assumed that the rapid decreases of incorporation of C¹⁴-leucine and C¹⁴-palmitic acid into the cell protein and lipid were the early sign of cell damage.