Lymphomatosis Cerebri with Intramedullary Spinal Cord Involvement

Hiroyasu Sato; Yoshimi Takahashi; Manabu Wada; Yousuke Shiono; Ikuko Suzuki; Kei Kohno; Yuichi Kato; Toru Kawanami; Kaori Sakurada; Takamasa Kayama; Takeo Kato

doi:10.2169/internalmedicine.52.0748

CASE REPORTS

Lymphomatosis Cerebri with Intramedullary Spinal Cord Involvement

Hiroyasu Sato, Yoshimi Takahashi, Manabu Wada, Yousuke Shiono, Ikuko Suzuki, Kei Kohno, Yuichi Kato, Toru Kawanami, Kaori Sakurada, Takamasa Kayama, Takeo Kato

Author information

Hiroyasu Sato
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Japan
Yoshimi Takahashi
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Japan
Manabu Wada
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Japan
Yousuke Shiono
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Japan
Ikuko Suzuki
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Japan
Kei Kohno
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Japan
Yuichi Kato
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Japan
Toru Kawanami
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Japan
Kaori Sakurada
Department of Neurosurgery, Yamagata University Faculty of Medicine, Japan
Takamasa Kayama
Department of Neurosurgery, Yamagata University Faculty of Medicine, Japan
Takeo Kato
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Japan

Keywords: diffuse large B cell lymphoma, intramedullary spinal cord tumor, leukoencephalopathy, lymphomatosis cerebri, magnetic resonance imaging, primary central nervous system lymphoma

JOURNAL OPEN ACCESS

2013 Volume 52 Issue 22 Pages 2561-2565

DOI https://doi.org/10.2169/internalmedicine.52.0748

Details

Abstract

Lymphomatosis cerebri (LC) is a rare form of primary central nervous system lymphoma (PCNSL). Little is known about cases of LC with spinal cord involvement. Among the 11 PCNSL patients treated in our hospital during a four-year period, we identified two cases of LC with spinal cord lesions. One showed a spinal cord lesion followed by leukoencephalopathy. The other showed a spinal cord lesion after LC. In both cases, the histopathology was diffuse large B-cell lymphoma. It is possible that LC may affect the entire central nerve system, and tumor infiltration to the brain and spinal cord in LC may occur more frequently than has been previously considered.

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