Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Kimura's Disease Associated with Membranous Nephropathy with IgG4 and Phospholipase A2 Receptor-positive Staining of the Glomerular Basement Membrane
Takafumi OkuraKen-ichi MiyoshiJun IritaDaijiro EnomotoTomoaki NagaoMasayoshi KukidaAkiko TaninoKayo KudoJitsuo Higaki
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JOURNALS OPEN ACCESS

2014 Volume 53 Issue 13 Pages 1435-1440

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Abstract

Kimura's disease is a granulomatous disease of unknown origin that develops in the dermis, subcutaneous tissue and lymph nodes. Kimura's disease is frequently complicated by nephropathy, particularly membranous nephropathy (MN). It has recently been suggested that glomerular immunoglobulin (IgG)4 deposition may play a role in the pathogenesis of idiopathic MN. These IgG4 antibodies are thought to react with antigens, primarily the phospholipase A2 receptor (PLA2R) expressed on the podocyte cell membrane. We herein report a case of Kimura's disease with MN in which a renal biopsy specimen revealed positive staining for anti-IgG4 and anti-PLA2R antibodies.

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© 2014 by The Japanese Society of Internal Medicine
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