Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Mediastinal Fibrosis and Positive Antineutrophil Cytoplasmic Antibodies: Coincidence or Common Etiology?
Hiroshi SantoOsamu NishiyamaHiroyuki SanoMasanori KitaichiHiroaki KumeYuji Tohda
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JOURNAL OPEN ACCESS

2014 Volume 53 Issue 3 Pages 275-277

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Abstract

Retroperitoneal fibrosis (RPF) with positive antineutrophil cytoplasmic antibodies (ANCA) has been reported in several cases. We herein present the case of a 52-year-old woman who was diagnosed with mediastinal fibrosis (MF) on a thoracoscopic surgical biopsy. The patient had positive myeloperoxidase ANCA and thereafter developed crescentic glomerulonephritis, which was considered to be a form of ANCA-related nephritis. Both the MF and crescentic glomerulonephritis favorably responded to immunosuppressive therapy. These findings suggest a common pathogenesis of these disorders involving ANCA positivity, as reported in patients with RPF.

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© 2014 by The Japanese Society of Internal Medicine
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