Multiple Colon Ulcers with Typical Small Intestinal Lesions Induced by Non-Steroidal Anti-Inflammatory Drugs

Momoko Akashi; Takayuki Ando; Takeru Hamashima; Hiroki Yoshita; Sohachi Nanjo; Hiroshi Mihara; Haruka Fujinami; Shinya Kajiura; Jun Nishikawa; Yoshiaki Miura; Ayumu Hosokawa; Toshiro Sugiyama

doi:10.2169/internalmedicine.54.3919

CASE REPORTS

Multiple Colon Ulcers with Typical Small Intestinal Lesions Induced by Non-Steroidal Anti-Inflammatory Drugs

Momoko Akashi, Takayuki Ando, Takeru Hamashima, Hiroki Yoshita, Sohachi Nanjo, Hiroshi Mihara, Haruka Fujinami, Shinya Kajiura, Jun Nishikawa, Yoshiaki Miura, Ayumu Hosokawa, Toshiro Sugiyama

Author information

Momoko Akashi
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Takayuki Ando
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Takeru Hamashima
Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
Hiroki Yoshita
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Sohachi Nanjo
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Hiroshi Mihara
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Haruka Fujinami
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Shinya Kajiura
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Jun Nishikawa
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Yoshiaki Miura
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Ayumu Hosokawa
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Toshiro Sugiyama
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan

Keywords: NSAID-induced ulcer, total colon, colonoscopy, capsule endoscopy

JOURNAL OPEN ACCESS

2015 Volume 54 Issue 16 Pages 1995-1999

DOI https://doi.org/10.2169/internalmedicine.54.3919

Details

Abstract

The diagnosis of NSAID-induced colon ulcers is difficult when the distribution or endoscopic findings are not typical. An 83-year-old woman was transferred to our hospital for hemorrhagic diarrhea. Colonoscopy showed multiple ulcers in the entire colon, particularly longitudinal ulcers in the transverse colon. These were unusual for NSAID-induced colopathy, although she had been on meloxicam. However, capsule endoscopy revealed multiple scars and erosions, characteristic of NSAIDs users. The final diagnosis was NSAID-induced enteropathy, and all lesions were in remission after meloxicam discontinuation. We herein emphasize the value of an endoscopic assessment of the entire digestive tract in the diagnosis of NSAID-induced mucosal lesions.

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