Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Development of Extranodal NK/T-cell Lymphoma Nasal Type in Cerebrum Following Epstein-Barr Virus-positive Uveitis
Ayano ImaiHiroshi TakaseKen-Ichi ImadomeGo MatsudaIichiro OhnishiKouhei YamamotoTakumi KudoYoji TanakaTaketoshi MaeharaOsamu MiuraAyako Arai
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JOURNALS OPEN ACCESS

2017 Volume 56 Issue 11 Pages 1409-1414

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Abstract

A 74-year-old woman developed bilateral uveitis with high Epstein-Barr virus (EBV) DNA load in the vitreous fluid without lymphoma cells. Four years after the onset, T2-weighted contrast-enhanced MRI revealed hyperintense lesions in the right occipital and parietal lobe. A biopsy resulted in the diagnosis of extranodal NK/T-cell lymphoma nasal type (ENKL). The repeat region of LMP1, an EBV gene, detected in the brain lesion was identical to that detected in the vitreous fluid. ENKL of the central nervous system is quite rare, and the pathogenesis has not been determined. The lymphoma in this case might have been closely associated with the EBV-positive uveitis.

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© 2017 by The Japanese Society of Internal Medicine
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