Hepatoid Adenocarcinoma of the Extrahepatic Bile Duct in a Patient with Polysplenia Syndrome

Kenji Yorita; Shiori Sasaki; Ai Kawada; Michiyo Okazaki; Hiromichi Yamai; Kunihisa Uchita; Shinichi Iwamura; Kimiko Nakatani; Satoshi Ito; Naoto Kuroda

doi:10.2169/internalmedicine.56.7526

CASE REPORTS

Hepatoid Adenocarcinoma of the Extrahepatic Bile Duct in a Patient with Polysplenia Syndrome

Kenji Yorita, Shiori Sasaki, Ai Kawada, Michiyo Okazaki, Hiromichi Yamai, Kunihisa Uchita, Shinichi Iwamura, Kimiko Nakatani, Satoshi Ito, Naoto Kuroda

Author information

Kenji Yorita
Department of Diagnostic Pathology, Japanese Red Cross Kochi Hospital, Japan
Shiori Sasaki
Department of Internal Medicine, Japanese Red Cross Kochi Hospital, Japan
Ai Kawada
Department of Internal Medicine, Japanese Red Cross Kochi Hospital, Japan
Michiyo Okazaki
Department of Internal Medicine, Japanese Red Cross Kochi Hospital, Japan
Hiromichi Yamai
Department of Surgery, Japanese Red Cross Kochi Hospital, Japan
Kunihisa Uchita
Department of Internal Medicine, Japanese Red Cross Kochi Hospital, Japan
Shinichi Iwamura
Department of Internal Medicine, Japanese Red Cross Kochi Hospital, Japan
Kimiko Nakatani
Department of Radiology, Japanese Red Cross Kochi Hospital, Japan
Satoshi Ito
Department of Radiology, Japanese Red Cross Kochi Hospital, Japan
Naoto Kuroda
Department of Diagnostic Pathology, Japanese Red Cross Kochi Hospital, Japan

Keywords: hepatoid adenocarcinoma, extrahepatic bile duct, polysplenia syndrome

JOURNAL OPEN ACCESS

2017 Volume 56 Issue 4 Pages 401-407

DOI https://doi.org/10.2169/internalmedicine.56.7526

Details

Abstract

Hepatoid adenocarcinoma (HAC) is a rare subtype of extrahepatic adenocarcinoma that is characterized by its morphological and functional similarities to hepatocellular carcinoma. We herein present a novel case of HAC arising from the extrahepatic bile duct in a 75-year-old Japanese woman with polysplenia syndrome. This is the second reported case of HAC arising from this site. The tumor induced jaundice and hemobilia. A total of four isolated intraductal polypoid masses of HAC were found. No recurrence was seen five months after surgery. Further reports of similar cases will be needed to clarify the clinical characteristics and the prognosis of this malignancy.

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