Cytokine Profile in Sweet's Syndrome under the Treatment of Pulmonary Toxoplasmosis Complicated with Myelodysplastic Syndrome

Yukimasa Matsuzawa; Eisuke Adachi; Atsuko Takahashi; Hidenori Sato; Lay Ahyoung Lim; Tsunehiko Komatsu; Tomohiko Koibuchi; Tokiko Nagamura-Inoue; Arinobu Tojo; Hitomi Nagayama; Hiroshi Yotsuyanagi

doi:10.2169/internalmedicine.2372-18

CASE REPORTS

Cytokine Profile in Sweet's Syndrome under the Treatment of Pulmonary Toxoplasmosis Complicated with Myelodysplastic Syndrome

Yukimasa Matsuzawa, Eisuke Adachi, Atsuko Takahashi, Hidenori Sato, Lay Ahyoung Lim, Tsunehiko Komatsu, Tomohiko Koibuchi, Tokiko Nagamura-Inoue, Arinobu Tojo, Hitomi Nagayama, Hiroshi Yotsuyanagi

Author information

Yukimasa Matsuzawa
Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of The Institute of Medical Science, The University of Tokyo, Japan
Eisuke Adachi
Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of The Institute of Medical Science, The University of Tokyo, Japan
Atsuko Takahashi
Department of Cell Processing and Transfusion, The Institute of Medical Science, The University of Tokyo, Japan
Hidenori Sato
Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of The Institute of Medical Science, The University of Tokyo, Japan
Lay Ahyoung Lim
Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of The Institute of Medical Science, The University of Tokyo, Japan
Tsunehiko Komatsu
Department of Hematology, Joban Hospital of Tokiwakai Group, Japan
Tomohiko Koibuchi
Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of The Institute of Medical Science, The University of Tokyo, Japan
Tokiko Nagamura-Inoue
Department of Cell Processing and Transfusion, The Institute of Medical Science, The University of Tokyo, Japan
Arinobu Tojo
Department of Hematology/Oncology, Research Hospital The Institute of Medical Science, The University of Tokyo, Japan
Hitomi Nagayama
Department of Hematology, Teikyo University Chiba Medical Center, Japan
Hiroshi Yotsuyanagi
Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of The Institute of Medical Science, The University of Tokyo, Japan

Keywords: Sweet's syndrome, toxoplasmosis, cytometric bead array, myelodysplastic syndrome

JOURNAL OPEN ACCESS

2019 Volume 58 Issue 14 Pages 2079-2083

DOI https://doi.org/10.2169/internalmedicine.2372-18

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Abstract

We herein describe a case of Sweet's syndrome (SS) in a patient being treated for pulmonary toxoplasmosis complicated with myelodysplastic syndrome (MDS). The patient's SS developed after the pulmonary toxoplasmosis improved following treatment. We searched his cytokine profiles comprehensively using a bead-based immunoassay. The results showed no elevation of interleukin (IL)-2, interferon (IFN)-γ or IL-17A, and IL-6 was only observed to have increased at the onset of SS, suggesting that the pulmonary toxoplasmosis had been well controlled and that chronic inflammation may have been the cause of SS. Pulmonary toxoplasmosis is an extremely rare occurrence. The cytokine profile can help to clarify the pathological condition of SS and MDS complicated with severely invasive infectious diseases.

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