Acute Myeloid Leukemia Developing with Acute Pancreatitis Mimicking Autoimmune Pancreatitis

Ryohei Sumitani; Taiki Hori; Jumpei Murai; Shiyori Kawata; Masahiro Oura; Kimiko Sogabe; Mamiko Takahashi; Takeshi Harada; Shiro Fujii; Hirokazu Miki; Kumiko Kagawa; Masahiro Abe; Shingen Nakamura

doi:10.2169/internalmedicine.4916-20

CASE REPORTS

Acute Myeloid Leukemia Developing with Acute Pancreatitis Mimicking Autoimmune Pancreatitis

Ryohei Sumitani, Taiki Hori, Jumpei Murai, Shiyori Kawata, Masahiro Oura, Kimiko Sogabe, Mamiko Takahashi, Takeshi Harada, Shiro Fujii, Hirokazu Miki, Kumiko Kagawa, Masahiro Abe, Shingen Nakamura

Author information

Ryohei Sumitani
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Taiki Hori
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Jumpei Murai
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Shiyori Kawata
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Masahiro Oura
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Kimiko Sogabe
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Mamiko Takahashi
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Takeshi Harada
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Shiro Fujii
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Hirokazu Miki
Division of Transfusion Medicine and Cell Therapy, Tokushima University Hospital, Japan
Kumiko Kagawa
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Masahiro Abe
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Shingen Nakamura
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan

Keywords: acute pancreatitis, autoimmune pancreatitis, acute myeloid leukemia

JOURNAL OPEN ACCESS

2021 Volume 60 Issue 11 Pages 1753-1757

DOI https://doi.org/10.2169/internalmedicine.4916-20

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Abstract

A 33-year-old man was admitted to our hospital for fever and abdominal pain. A blood analysis revealed pancytopenia and increased serum pancreatic enzymes with disseminated intravascular coagulation. A detailed examination revealed acute pancreatitis, with diffuse swelling of the pancreas and diffuse beaded dilatation of the main pancreatic duct, which mimicked autoimmune pancreatitis complicated by acute myeloid leukemia. Systemic cytotoxic chemotherapy led to the remission of leukemia and pancreatitis. We hypothesized that the etiology of acute pancreatitis was invasion of leukemia cells. Acute pancreatitis is rare as a symptom of leukemia; however, we should consider the possibility of leukemia during the differential diagnosis of acute pancreatitis.

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