Carney Complex Complicated with Primary Pigmented Nodular Adrenocortical Disease without Cushing's Syndrome Recurrence for Five Years after Unilateral Adrenalectomy

Yuya Tsurutani; Kanako Kiriyama; Mai Kondo; Masanori Hasebe; Akira Sata; Yuzo Mizuno; Chiho Sugisawa; Jun Saito; Tetsuo Nishikawa

doi:10.2169/internalmedicine.7418-21

CASE REPORTS

Carney Complex Complicated with Primary Pigmented Nodular Adrenocortical Disease without Cushing's Syndrome Recurrence for Five Years after Unilateral Adrenalectomy

Yuya Tsurutani, Kanako Kiriyama, Mai Kondo, Masanori Hasebe, Akira Sata, Yuzo Mizuno, Chiho Sugisawa, Jun Saito, Tetsuo Nishikawa

Author information

Yuya Tsurutani
Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Japan
Kanako Kiriyama
Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Japan
Mai Kondo
Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Japan
Masanori Hasebe
Division of Endocrinology and Metabolism, Kanto Central Hospital, Japan
Akira Sata
Division of Endocrinology and Metabolism, Kanto Central Hospital, Japan
Yuzo Mizuno
Division of Endocrinology and Metabolism, Kanto Central Hospital, Japan
Chiho Sugisawa
Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Japan
Jun Saito
Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Japan
Tetsuo Nishikawa
Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Japan

Keywords: Carney complex, primary pigmented nodular adrenocortical disease, unilateral adrenalectomy, Cushing's syndrome

JOURNAL OPEN ACCESS

2022 Volume 61 Issue 2 Pages 205-211

DOI https://doi.org/10.2169/internalmedicine.7418-21

Details

Abstract

We herein report a case of Carney complex (CNC) complicated with primary pigmented nodular adrenocortical disease (PPNAD) after unilateral adrenalectomy. A 44-year-old woman was admitted to our hospital for PPNAD surgery. She had previously undergone surgery for cardiac myxoma and had a PRKAR1A mutation with no family history of CNC. She had Cushing's signs, but her metabolic abnormalities were mild. Adrenal insufficiency due to poor medication adherence was a concern, so she underwent unilateral adrenalectomy. Cushing's signs improved postoperatively and without recurrence for five years. Treatment plans for PPNAD should be determined based on the patient's condition, medication adherence, and wishes.

Corresponding author

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