Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Temporal Changes in Brain Perfusion in a Patient with Myoclonus and Ataxia Syndrome Associated with COVID-19
Kenta OsawaAtsuhiko SugiyamaAkiyuki UzawaShigeki HiranoTatsuya YamamotoMasahiko NezuNobuyuki ArakiHiroki KanoSatoshi Kuwabara
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JOURNAL OPEN ACCESS

2022 Volume 61 Issue 7 Pages 1071-1076

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Abstract

Myoclonus and ataxia, with or without opsoclonus, have recently been recognized as a central nervous system syndrome associated with coronavirus disease-2019 (COVID-19). A 52-year-old Japanese man developed myoclonus and ataxia 16 days after the onset of COVID-19. Brain single-photon emission computed tomography (SPECT) revealed hyperperfusion in the cerebellum and hypoperfusion in the cerebral cortices with frontal predominance during the acute stage, which improved over two months. This study indicates that brain perfusion SPECT can be effective in detecting functional alterations in COVID-19-related myoclonus and ataxia.

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© 2022 by The Japanese Society of Internal Medicine
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