A Case of Hereditary Diffuse Gastric Cancer Treated by Prophylactic Total Gastrectomy: A Case Report

Yasunori Inaba; Kenichi Goda; Masayuki Kondo; Keiichiro Abe; Akira Kanamori; Tsunehiro Suzuki; Keiichi Tominaga; Masatoshi Nakagawa; Shinji Morita; Kazuyuki Kojima; Kazuyuki Ishida; Atsushi Irisawa

doi:10.2169/internalmedicine.1257-22

This article has now been updated. Please use the final version.

A Case of Hereditary Diffuse Gastric Cancer Treated by Prophylactic Total Gastrectomy: A Case Report

Yasunori Inaba, Kenichi Goda, Masayuki Kondo, Keiichiro Abe, Akira Kanamori, Tsunehiro Suzuki, Keiichi Tominaga, Masatoshi Nakagawa, Shinji Morita, Kazuyuki Kojima, Kazuyuki Ishida, Atsushi Irisawa

Author information

Yasunori Inaba
Department of Gastroenterology, Dokkyo Medical University, Japan
Kenichi Goda
Department of Gastroenterology, Dokkyo Medical University, Japan
Masayuki Kondo
Department of Gastroenterology, Dokkyo Medical University, Japan
Keiichiro Abe
Department of Gastroenterology, Dokkyo Medical University, Japan
Akira Kanamori
Department of Gastroenterology, Dokkyo Medical University, Japan
Tsunehiro Suzuki
Department of Gastroenterology, Dokkyo Medical University, Japan
Keiichi Tominaga
Department of Gastroenterology, Dokkyo Medical University, Japan
Masatoshi Nakagawa
Department of Upper Gastrointestinal Surgery, Dokkyo Medical University, Japan
Shinji Morita
Department of Upper Gastrointestinal Surgery, Dokkyo Medical University, Japan
Kazuyuki Kojima
Department of Upper Gastrointestinal Surgery, Dokkyo Medical University, Japan
Kazuyuki Ishida
Department of Diagnostic Pathology, Dokkyo Medical University, Japan
Atsushi Irisawa
Department of Gastroenterology, Dokkyo Medical University, Japan

Keywords: hereditary diffuse gastric cancer, CDH1, signet ring cell carcinoma, endoscopic submucosal dissection, prophylactic gastrectomy

JOURNAL OPEN ACCESS Advance online publication

Article ID: 1257-22

DOI https://doi.org/10.2169/internalmedicine.1257-22

The final version of this article is now available: Vol. 63 (2024), No. 2 pp. 235-239

Details

Abstract

We herein report a rare case of hereditary diffuse gastric cancer in a Japanese man. A 41-year-old man underwent esophagogastroduodenoscopy which revealed a small gastric erosion. Biopsy specimens showed signet ring cell carcinoma, and endoscopic submucosal dissection was performed. The patient's elder sister had died of gastric cancer at 38 years old. Considering the family history, a genetic test was conducted and revealed a CDH1 germline mutation. Although no carcinomatous lesion was detected endoscopically, prophylactic total gastrectomy was performed. The resection specimen showed seven microlesions of signet ring cell carcinoma confined to the lamina propria mucosae.

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