Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Transbronchial Mediastinal Cryobiopsy in Diagnosing Sarcoidosis: A Three-Case Report
Chieri YamadaRyota OtoshiEri HagiwaraAsami MoriuchiYoichi TagamiTakashi NiwaTomohisa BabaTomoe SawazumiTamiko TakemuraTakashi Ogura
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JOURNAL OPEN ACCESS Advance online publication

Article ID: 5415-25

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Abstract

Recent reports suggest that a transbronchial mediastinal cryobiopsy (TMC) offers a better diagnostic performance for benign diseases than endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) because it can obtain larger specimens. We herein report the utility of TMC in three patients with sarcoidosis at our institution. EBUS-TBNA failed to diagnose sarcoidosis in all three patients, whereas TMC provided a definitive diagnosis. Although no significant differences in either the safety or procedural complexity were observed between TMC and EBUS-TBNA, the cost of TMC remains a considerable challenge. Further research is required to determine the strategies regarding optimal patient selection for sarcoidosis patients who need a diagnosis of TMC.

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© 2025 by The Japanese Society of Internal Medicine

This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license.
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