抄録
Thirty eight untreated diabetics underwent insulin-induced hypoglycemia and supplemental glucagon secretion was determined. The diabetic patients were classified according to levels of FBS; group A (FBS^130mg/dl), group B (130<FBS<200mg/dl), group C (FBS^200 mg/dl). The ratio of the sum of plasma glucagon increment and blood sugar decrement from the fasting level, JJIRG/JJ-BS, was calculated. The value was 2.1±0.31 in healthy subjects, 0.61±0.11 in group A, 0.13±0.03 in group B, and 0.08±0.04 in group C. It was recognized that in diabetic subjects supplemental secretion of glucagon in response to hypoglycemic stimulation decreased in relation to the elevation of FBS. The value was also observed to correlate with the insulinogenic index (y=0.81x+0.12, r=0.657). When severe diabetics received a second hypoglycemic test after therapeutic diabetes control, supplemental glucagon secretion was still absent even though glucose decreasing patterns were similar to normal subjects. It is concluded that in diabetic subjects, in addition to pancreatic β-cell insulin secretory function, the α-cell glucagon secretory mechanism is also disturbed.
