Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Hypereosinophilic Syndrome Accompanied with Necrosis of Finger Tips
Mutsuhiro TAKEKAWAKohzoh IMAIMasaaki ADACHIShigeo AOKIKazuo MAEDAYuji HINODAAkira YACHI
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1992 Volume 31 Issue 11 Pages 1262-1266

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Abstract

We report a case of hypereosinophilic syndrome (HES) with marked eosinophilia (59.7%) and mononeuritis multiplex (upper limbs and buttocks). Necrosis of the finger tips was the primary manifestation which simultaneously occurred on both sides. These clinical manifestations were improved dramatically by subsequent steroid therapy. Interestingly, an elevation of serum tumor necrosis factor (TNF) was observed. These findings suggest that TNF may play a role in the etiology of necrosis of the finger tips.
(Internal Medicine 31 : 1262-1266, 1992)

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