Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Anaplastic Thyroid Carcinoma with Prominent Cardiac Metastasis, Accompanied by a Marked Leukocytosis with a Neutrophilia and High GM-CSF Level in Serum
Hiroyuki MURABETakashi AKAMIZUAkira KUBOTAShohei KUSAKA
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Keywords: high fever, cytokine
JOURNAL FREE ACCESS

1992 Volume 31 Issue 9 Pages 1107-1111

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Abstract
Cardiac metastasis of thyroid carcinoma is extremely rare. We treated a case of anaplastic thyroid carcinoma with prominent cardiac metastasis. The 61-year-old male was admitted because of high fever. Investigations revealed a cardiac mass and anaplastic thyroid carcinoma. Resection of the cardiac mass revealed that it was metastasis from the thyroid carcinoma. After 4 months, he died in spite of intensive therapy. Marked leukocytosis was observed during the clinical course, and a concomitant increase of granulocyte macrophage-colony stimulating factor (GM-CSF) level was demonstrated in the sera. It was suggested that the high GM-CSF level in serum contributed to leukocytosis.
(Internal Medicine 31 : 1107-1111, 1992)
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© The Japanese Society of Internal Medicine
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