Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Volume 31 , Issue 9
Showing 1-21 articles out of 21 articles from the selected issue
  • Satoru MINESHITA, Ding TIAN, Li-man WANG, Xiu-Yi JIAN, Shi-Yin LI, Gao ...
    1992 Volume 31 Issue 9 Pages 1073-1075
    Published: 1992
    Released: March 27, 2006
    JOURNALS FREE ACCESS
    Among Han nationality Chinese and living in the northern area of the Yellow River, 120 patients suffering from Behcet's disease and 100 unrelated healthy individuals were typed for histocompatibility antigens (HLA)-A, -B, -C, and -DR and -DQ antigens. HLA-DR and DQ typing was performed on B-lymphocyte separated with Lympho-B-Kwik. The HLA-antisera were provided by 11th IHWC. Bf alleles and C4 allotypes were determined by immunofixation agarose-gel electrophoresis. HLA-B51 was found in 67/120 (55.83%) patients and in 12/100 (12%) controls, the Chi-square and relative risk values were 45.54 and 9.27, respectively (p<0.0005). C4AQ0 frequency was significantly increased in the patient group. In the complete form group HLA-B51 was observed more frequently (62.79%). No significant differences of other HLA antigens, frequencies, Bf or B4 alleles were found between the groups.
    (Internal Medicine 31 : 1073-1075, 1992)
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  • Nobuhiro CHIKUBA, Shoichi AKAZAWA, Yoshihiko YAMAGUCHI, Eiji KAWASAKI, ...
    1992 Volume 31 Issue 9 Pages 1076-1080
    Published: 1992
    Released: March 27, 2006
    JOURNALS FREE ACCESS
    Type 1 diabetes mellitus is known to be a heterogenous disease which is frequently complicated with other autoimmune thyroid diseases (AITD). The present study was designed to investigate the clinical characteristics and HLA antigens in Japanese Type 1 diabetic patients with AITD. Subjects were 25 Type 1 diabetic patients with AITD (13 Graves' disease and 12 Hashimoto's thyroiditis) and 32 Type 1 diabetic patients without AITD. Compared with Type 1 diabetic patients without AITD, age at onset of diabetes was later and positive ICA persisted much longer in the diabetic patients with AITD. Compared with normal controls, DR9 was increased in the patients with AITD, while DR4 was increased in those without AITD. Type 1 diabetic patients with AITD were characterized by the late onset of diabetes, persistent ICA and increased association with DR9. These results suggest that immunological and genetic heterogeneity may exist within Japanese Type 1 diabetic patients.
    (Internal Medicine 31 : 1076-1080, 1992)
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  • Kohji SHIBAYAMA, Tatsufumi NAKAMURA, Ikuo KINOSHITA, Yukitaka UEKI, Hi ...
    1992 Volume 31 Issue 9 Pages 1081-1083
    Published: 1992
    Released: March 27, 2006
    JOURNALS FREE ACCESS
    We used two-color flow cytometric analysis to investigate CD26+ (Ta1+) cells in peripheral blood T lymphocytes from patients with human T-lymphotropic virus type-I (HTLV-I) - associated myelopathy (HAM). The percentage of CD26+ cells among CD3+ cells was markedly increased in patients with HAM, compared with anti-HTLV-I seropositive carriers (p<0.001) and seronegative controls (p<0.01). Within the subpopulation of T cells, a significantly high percentage of CD26+ cells was detected in both CD4+ and CD8+ cell populations. Furthermore, analysis of HLA-DR+T cells revealed similar results. In contrast CD4+CD45RA+ cells were significantly decreased in comparison with controls. These results suggest that immunologically activated or memory T cells found in peripheral blood may be etiologically relevant to HAM.
    (Internal Medicine 31 : 1081-1083, 1992)
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  • Yukio MANO, Takuya NAKAMURO, Katsunori IKOMA, Tadao SUGATA, Shigeru MO ...
    1992 Volume 31 Issue 9 Pages 1084-1087
    Published: 1992
    Released: March 27, 2006
    JOURNALS FREE ACCESS
    The conductivity of motor neurons in 26 aged females (mean age 79 years) was analyzed by the conventional conduction method and by pulsed magnetic stimulation and compared with that in 14 younger controls. In aged people, slow motor conduction velocities were found in peripheral nerves. Central motor conduction time (CMCT) in relaxed muscle was shorter in the aged people, although CMCT was normal in mildly contracted muscle. These findings coincide with the results studied in Parkinson's disease, although these subjects were not diagnosed as having Parkinson's disease. Aged people generally have an anteflexed posture, slow movements, and poor postural reflexes, and have been reported to have a decrease in the dopamine level which is relatively earlier than that of other transmitters in the basal ganglia. This may account for the present finding that aged people have neurophysiological abnormalities in CNS which are similar to those in Parkinson's disease.
    (Internal Medicine 31 : 1084-1087, 1992)
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  • Yoshiaki MASUDA, Kazunori TAKANASHI, Junichiro TAKASU, Yutaka AOYAGI, ...
    1992 Volume 31 Issue 9 Pages 1088-1093
    Published: 1992
    Released: March 27, 2006
    JOURNALS FREE ACCESS
    The purpose of this study was to evaluate the long-term prognosis of unoperated thoracic aortic aneurysms, and to detect the risk factors which determine the prognosis of unoperated patients. The subjects were 52 unoperated patients with 58 thoracic aortic aneurysms (22 of the ascending aorta, 36 of the descending aorta or the aortic arch) and 38 with abdominal aortic aneurysms. The survival rates of the patients with ascending aortic aneurysms at 3 years and 5 years and those of the patients with descending aortic aneurysms at 5 years were significantly higher than those of the patients with abdominal aortic aneurysms. The risk factors for rupture of thoracic aortic aneurysms were the large size of aneurysms and non-management by the cardiologist and the risk factors for death unrelated to the aneurysms were patient age, male gender and non-management by the cardiologist.
    (Internal Medicine 31 : 1088-1093, 1992)
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  • Yasurou KAWAZOE, Yutaka OTSUJI, Akira KISANUKI, Hiromitsu TANAKA
    1992 Volume 31 Issue 9 Pages 1094-1097
    Published: 1992
    Released: March 27, 2006
    JOURNALS FREE ACCESS
    In three patients with hypertrophic cardiomyopathy, a late systolic click following mid systolic murmur was recognized. M-mode and two-dimensional echocardiography showed the presence of systolic anterior motion of the chordae tendineae in all cases. Phonoechocardiographic studies showed that the time of the click always coincided with the endpoint of mild anterior motion of the chordae tendineae. The click was considered to be a chordal snap.
    (Internal Medicine 31 : 1094-1097, 1992)
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  • Ikuya SAKAI, Tomoo SHIROGUCHI, Hideaki KANEGAE, Isao MATUMOTO
    1992 Volume 31 Issue 9 Pages 1098-1101
    Published: 1992
    Released: March 27, 2006
    JOURNALS FREE ACCESS
    Although many cases of Waldenstrom's macroglobulinemia (WMG) with pulmonary involvement have been reported, endobronchial involvement has not been described. We report an unusual case of WMG wherein endobronchial invasion of tumor cells narrowed the airways and caused coughing and wheezing.
    (Internal Medicine 31 : 1098-1101, 1992)
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  • Shigeru NAKANO, Atsuko SASAME, Sadahide AZUKIZAWA, Toshikazu KIGOSHI, ...
    1992 Volume 31 Issue 9 Pages 1102-1106
    Published: 1992
    Released: March 27, 2006
    JOURNALS FREE ACCESS
    Pentasomy X mosaic in two adult sisters with non-insulin dependent diabetes mellitus is described. The younger sister had schizophrenia, and both were mentally retarded, but no apparent somatic abnormalities were found. Chromosome analyses revealed karyotype 45, X/46, XX/47, XXX/48, XXXX/49, XXXXX mosaic with a low frequency of aneuploidy on cultured peripheral lymphocytes and 46, XX on cultured skin fibroblasts in both sisters. The low frequency of X chromosome aberration may be responsible for the lack of somatic abnormalities and the long life in both sisters. The association of pentasomy X mosaicism and diabetes mellitus however appears to be coincidental.
    (Internal Medicine 31 : 1102-1106, 1992)
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  • Hiroyuki MURABE, Takashi AKAMIZU, Akira KUBOTA, Shohei KUSAKA
    1992 Volume 31 Issue 9 Pages 1107-1111
    Published: 1992
    Released: March 27, 2006
    JOURNALS FREE ACCESS
    Cardiac metastasis of thyroid carcinoma is extremely rare. We treated a case of anaplastic thyroid carcinoma with prominent cardiac metastasis. The 61-year-old male was admitted because of high fever. Investigations revealed a cardiac mass and anaplastic thyroid carcinoma. Resection of the cardiac mass revealed that it was metastasis from the thyroid carcinoma. After 4 months, he died in spite of intensive therapy. Marked leukocytosis was observed during the clinical course, and a concomitant increase of granulocyte macrophage-colony stimulating factor (GM-CSF) level was demonstrated in the sera. It was suggested that the high GM-CSF level in serum contributed to leukocytosis.
    (Internal Medicine 31 : 1107-1111, 1992)
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  • Mikio TOYOSHIMA, Atsuhiko SATO, Yoshihiro FUKUMOTO, Masami TANIGUCHI, ...
    1992 Volume 31 Issue 9 Pages 1112-1116
    Published: 1992
    Released: March 27, 2006
    JOURNALS FREE ACCESS
    Partial anomalous pulmonary venous return (PAPVR) is a congenital heart disease with a reported incidence of autopsied case. The location of the anomalous pulmonary venous return is usually the right atrium, superior vena cava (SVC), and sometimes the brachiocephalic vein, inferior vena cava (IVC) or coronary venous sinus. Recently we experienced a rare case of PAPVR showing anomalous right total pulmonary venous return to the azygos vein. Furthermore, downward translocation of the right upper lobe bronchus was evident. This rare case is reported along with a review of the related literature.
    (Internal Medicine 31 : 1112-1116, 1992)
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  • Masahiro YAMAMOTO, Hiroshi HOSHINO, Toshio ONIZUKA, Masafumi ICHIKAWA, ...
    1992 Volume 31 Issue 9 Pages 1117-1119
    Published: 1992
    Released: March 27, 2006
    JOURNALS FREE ACCESS
    We present a rare case of Peutz-Jeghers (P-J) syndrome in a 29-year-old woman who developed adenocarcinoma of the thyroid and polyps in the gastrointestinal tract. Polyps removed from the stomach, colon and ileum showed features typical of hamartomas. Histological examination indicated that the tumor resected from the right lobe of the thyroid was a papillary adenocarcinoma. This appears to be the first precise report of a P-J syndrome associated with thyroid carcinoma. This case adds an example of predisposition of P-J syndrome to extraintestinal malignancy and indicates the importance of long-term observation of malignancy.
    (Internal Medicine 31 : 1117-1119, 1992)
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  • Takashi OGAWA, Yukiyasu FUJISE, Shingo SHIBATA, Masayoshi ABIRU, Yoshi ...
    1992 Volume 31 Issue 9 Pages 1120-1124
    Published: 1992
    Released: March 27, 2006
    JOURNALS FREE ACCESS
    A 45-year-old woman with Bartter's syndrome complicated with gouty arthritis is reported. Bartter's syndrome was diagnosed from hypokalemia, metabolic alkalosis, high plasma renin activity, normal blood pressure and attenuated pressor response to exogenous angiotensin II infusion. Serum uric acid was 11.8mg/dl, the renal clearance of uric acid was low (3.0ml/min) and fractional excretion of uric acid (FEUA) was 7.0%, being the lower limit of the normal range. Fractional excretion of phosphate was low (5.3%) and fractional free water clearance per fractional distal sodium delivery was 0.51. The mechanism of hyperuricemia in this case is discussed.
    (Internal Medicine 31 : 1120-1124, 1992)
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  • Hiroshi NEMOTO, Kyoko MURABAYASHI, Yuko KAWAMURA, Kenji SASAKI, Nobuo ...
    1992 Volume 31 Issue 9 Pages 1125-1127
    Published: 1992
    Released: March 27, 2006
    JOURNALS FREE ACCESS
    A 37-year-old male, a poorly-controlled insulin-dependent diabetic patient, was admitted to our hospital with complaints of high fever and confusion. Laboratory data showed hyperglycemia, positive inflammatory reaction and liver dysfunction. Blood culture demonstrated Yersinia enterocolitica. Liver CT scan showed multiple low density areas. These data were consistent with a diagnosis of liver abscess secondary to Yersinia enterocolitica. He died of disseminated intravascular coagulation ; subsequent autopsy confirmed the clinical diagnosis. Liver abscess secondary to Yersinia enterocolitica with septicemia is rare, but has been reported in compromised hosts. In the mechanism of this disease, the alimentary tract has been suggested to be the port of entry in most cases.
    (Internal Medicine 31 : 1125-1127, 1992)
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  • Hiroyuki OHASHI, Mitsuyasu ITOH, Noriyoshi OGAWA, Yuichiro SUDO, Shige ...
    1992 Volume 31 Issue 9 Pages 1128-1131
    Published: 1992
    Released: March 27, 2006
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    A 38-year-old woman with rheumatoid arthritis who developed Wegener's granulomatosis is described. Wegener's granulomatosis appeared with saddle nose, perforation in her nasal septum, and granuloma in the nasal cavity. Laboratory evaluation showed a positive rheumatoid factor and circulating immune complex. Radiographic examination revealed ankylotic changes in both wrist and elbow joints. Bilateral anosmia and other disease manifestations completely responded to treatment with oral cyclophosphamide and prednisolone.
    (Internal Medicine 31 : 1128-1131, 1992)
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  • Takayoshi TASHIRO, Tohru YAMASAKI, Hiroyuki NAGAI, Hiroshi KIKUCHI, Ma ...
    1992 Volume 31 Issue 9 Pages 1132-1136
    Published: 1992
    Released: March 27, 2006
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    Three patients with opportunistic infection preceding adult T-cell leukemia (ATL) are presented : a 66-year-old woman with cryptococcosis and Pneumocystis carinii pneumonia, a 46-year-old man with Pneumocystis carinii pneumonia, and a 55-year-old woman with cryptococcosis. Although, at the first examination, the first two had smoldering type ATL and the third case was an HTLV-I carrier, all three developed overt ATL 14-16 months after the onset of opportunistic infection. It is considered that there is immune suppression already present in HTLV-I carriers and in patients with smoldering ATL, and opportunistic infection is predictive of the development of ATL.
    (Internal Medicine 31 : 1132-1136, 1992)
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  • Taizo TASAKA, Masami NAGAI, Kazuma IKEDA, Kazunori SASAKI, Michio MURA ...
    1992 Volume 31 Issue 9 Pages 1137-1138
    Published: 1992
    Released: March 27, 2006
    JOURNALS FREE ACCESS
    This report describes pneumococcal meningitis in two splenectomized patients with lymphoid malignancy. Early diagnosis and emergency treatment of pneumococcal infection in splenectomized patients is proven to be of significant value. Prophylactic antibiotics targeted against pneumococcus should be considered for the clinical management of such conditions in splenectomized patients, particularly during cytotoxic chemotherapy.
    (Internal Medicine 31 : 1137-1138, 1992)
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  • Makoto NISHIO, Masahiro OHATA, Tadatoshi SURUDA, Kousaku UETANI, Hisas ...
    1992 Volume 31 Issue 9 Pages 1139-1143
    Published: 1992
    Released: March 27, 2006
    JOURNALS FREE ACCESS
    A previously healthy young man presented with acute respiratory distress, high fever and bilateral ground-glass appearance on chest radiograph. Bronchoalveolar lavage analysis demonstrated significant eosinophilia (72%) with no evidence of infection. The transbronchial lung biopsy showed that the walls of bronchioli and alveolar septa were markedly infiltrated with eosinophils. The patient rapidly improved with corticosteroid therapy. This case exemplifies the recently described idiopathic acute eosinophilic pneumonia. Similar cases published in the Japanese literature were reviewed and discussed.
    (Internal Medicine 31 : 1139-1143, 1992)
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  • Masayuki BABA, Akinori TERADA, Ryohei HISHIDA, Muneo MATSUNAGA, Yasuno ...
    1992 Volume 31 Issue 9 Pages 1144-1146
    Published: 1992
    Released: March 27, 2006
    JOURNALS FREE ACCESS
    We describe a case with unilateral chorea associated with thyrotoxicosis. A 23-year-old female with no family history of neurological diseases acutely developed choreic movements of the left extremities during gross thyrotoxicosis. CT scan and MRI study demonstrated no abnormality. Single-photon emission CT with technetium Tc 99m-labeled hexamethylpropyleneamine oxime revealed normal cerebral perfusion. Although the choreic movements were partially improved by dopamine antagonist, they persisted for two months until successful treatment of the thyrotoxicosis finally abolished these movements. Increased sensitivity of dopamine receptors may be responsible for persistent choreic movements in thyrotoxicosis.
    (Internal Medicine 31 : 1144-1146, 1992)
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  • Mitsuaki YOSHIOKA, Norio YAMAKAWA, Hideaki SAITO, Makoto YONEDA, Toru ...
    1992 Volume 31 Issue 9 Pages 1147-1150
    Published: 1992
    Released: March 27, 2006
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    We report an unusual case of granulomatous hypophysitis in which visual impairment, meningitis and hypopituitarism in a 76-year-old female were associated with radiological evidence of a pituitary mass. The sellar lesion was indistinguishable from pituitary tumor on neuroimaging studies, but the recovery of visual acuity and visual field abnormalities together with the improvement of pituitary function after steroid administration indicated that the mass lesion was due to an inflammatory disease of the pituitary gland. The pituitary tissue obtained by transsphenoidal hypophysectomy revealed granulomatous inflammatory cell infiltration with epithelioid cells and scattered multinucleated giant cells. Although a causal relationship with meningitis was not ascertained, possible exposure of the CSF space to the autoimmune inflammatory process of the pituitary gland was likely in view of the positive pituitary antibody reaction and radiological evidence of suprasellar extension. This entity should be considered when evaluating patients with a pituitary mass, hypopituitarism and meningitis.
    (Internal Medicine 31 : 1147-1150, 1992)
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  • Takashi ABE, Akira YACHI, Yoshiroh ISHII, Tomofumi IGARASHI, Hiroshi T ...
    1992 Volume 31 Issue 9 Pages 1151-1154
    Published: 1992
    Released: March 27, 2006
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    A 54-year-old man was diagnosed with hereditary spherocytosis. An X-ray of the chest disclosed bilateral round masses in the upper and lower posterior mediastinum. CT showed homogeneous round masses of soft tissue density in the posterior mediastinum. A needle biopsy of the mass showed hyperplastic erythroid bone marrow. Fatty metamorphosis of the masses was observed in CT 2 years after splenectomy but showed no change in size.
    (Internal Medicine 31 : 1151-1154, 1992)
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  • Esteban Cesar GABAZZA, Osamu TAGUCHI, Tomoya YAMAKAMI, Motoko MACHISHI ...
    1992 Volume 31 Issue 9 Pages 1155-1159
    Published: 1992
    Released: March 27, 2006
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    Two cases of ulcerative colitis are described : a 33-year-old woman who developed widespread bronchiectasis 7 months after undergoing colectomy, and a 72-year-old man whose colonic disease began coincidentally with the appearance of diffuse interstitial pulmonary infiltrates. In both cases, clinical correlation and common patterns of response of lung and bowel diseases suggested that the co-existence of these two pathologies might not be merely a casual relation.
    (Internal Medicine 31 : 1155-1159, 1992)
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