Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Malignant Insulinoma which Expressed a Unique Creatine Kinase Isoenzyme: Clinical Value of Arterial Embolization as a Palliative Therapy
Michio HAYASHIKenmei TAKAICHIToshitsugu KARIYAHiroki KANBENaoto HAYASHIMasako HONSEIShuhei HAYASHIHiroshi YASUDATomoko UENOToshiro FUJITA
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2000 Volume 39 Issue 6 Pages 474-477

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Abstract

A 76-year-old man with hypoglycemic coma was diagnosed as malignant insulinoma with multiple hepatic metastases. Embolization was done for two-thirds of the hepatic mass and it rapidly lowered the serum immunoreactive insulin. He was discharged without medication and has been free from hypoglycemia. After the embolization, the serum creatine kinase (CK) level increased transiently although there was no evidence of myocardial infarction. On electrophoresis, the CK activity showed an abnormal peak, suggesting mitochondrial CK. CK release after embolization has been reported in only a few cases with endocrine tumors, which might indicate some relationship between active energy metabolism and mitochondrial CK.
(Internal Medicine 39: 474-477, 2000)

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