Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Volume 39 , Issue 6
Showing 1-24 articles out of 24 articles from the selected issue
  • Hirobumi KONDO
    2000 Volume 39 Issue 6 Pages 437
    Published: 2000
    Released: March 27, 2006
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  • Tanenao ETO
    2000 Volume 39 Issue 6 Pages 438-439
    Published: 2000
    Released: March 27, 2006
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  • Masafumi FUKAGAWA
    2000 Volume 39 Issue 6 Pages 440-441
    Published: 2000
    Released: March 27, 2006
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  • Kiyoshi HASHIZUME
    2000 Volume 39 Issue 6 Pages 442-443
    Published: 2000
    Released: March 27, 2006
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  • Eizo KAKISHITA
    2000 Volume 39 Issue 6 Pages 444-445
    Published: 2000
    Released: March 27, 2006
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  • Tatsuya ATSUMI, Takao KOIKE
    2000 Volume 39 Issue 6 Pages 446-447
    Published: 2000
    Released: March 27, 2006
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  • Masao KINOSHITA
    2000 Volume 39 Issue 6 Pages 448
    Published: 2000
    Released: March 27, 2006
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  • Hiroshi HASHIMOTO
    2000 Volume 39 Issue 6 Pages 449-450
    Published: 2000
    Released: March 27, 2006
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  • Yuji AKIYAMA, Masahiko TANAKA, Michio TAKEISHI, Daisuke ADACHI, Akio M ...
    2000 Volume 39 Issue 6 Pages 451-456
    Published: 2000
    Released: March 27, 2006
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    Objective To assess the clinical, serological and genetic features of Japanese patients with CREST syndrome.
    Patients and Methods Clinical features, autoantibodies and human histocompatibility leukocyte antigen (HLA) typing were studied in thirty patients with CREST syndrome, including 29 females and one male, with a mean age of 59.0 years (ranging from 40 to 76 years).
    Results Interstitial pneumonia on chest X-ray and renal involvement were rare. Mitral regurgitation and tricuspid regurgitation were present in 56.7% and 76.7%, respectively. Sjören's syndrome (SS) and primary biliary cirrhosis (PBC) were highly associated, however the positivity of the marker antibodies to those syndromes, such as anti-SSA, anti-SSB, anti-mitochondrial (AMA) and antismooth muscle autoantibodies were less frequent than that of primary SS and PBC without the other autoimmune diseases. The histological findings of PBC were all early stages in Scheuer's classification. HLA-Cw6 were associated with CREST-PBC overlap syndrome (p<0.05). However the HLA antigen was not correlated with CREST syndrome, and the frequency of HLA-DR2 between CREST syndrome with or without PBC was significantly different (p<0.01).
    Conclusion It was suggested that there was a genetic difference between CREST syndrome alone and CREST-PBC overlap syndrome and there were differences (the positivity of AMA and the severity of bile duct lesion) between PBC and CREST-PBC overlap syndrome.
    (Internal Medicine 39: 451-456, 2000)
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  • Tomoko OHARA, Yoshihisa ITOH, Kouichi ITOH
    2000 Volume 39 Issue 6 Pages 457-463
    Published: 2000
    Released: March 27, 2006
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    Objective We reevaluated the diagnostic value of laboratory parameters in relation to histopathological findings in Sjöögren's syndrome (SS) to clarify whether autoantibodies are useful diagnostic criteria for SS, and whether any laboratory data are useful in estimating the degree of salivary gland change.
    Patients and Methods Laboratory parameters and histopathological findings were analyzed in 96 patients examined by labial biopsy.
    Results The percentage of cases with positive assays of rheumatoid factor and anti-SS-A/Ro antibodies was significantly higher in Definite SS. Patients with dense mononuclear cell infiltration of salivary tissues also had higher titers of rheumatoid factor. No useful laboratory parameters were found for the diagnosis of secondary SS.
    Conclusion Rheumatoid factor and anti-SS-A/Ro antibodies are useful for the diagnosis of primary SS, and rheumatoid factor is also an indicator of the severity of salivary glandular damage.
    (Internal Medicine 39: 457-463, 2000)
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  • Mitsutaka KITAZAWA, Hiroyasu TAMAMURA, Shigeru NAKANO, Toshikazu KIGOS ...
    2000 Volume 39 Issue 6 Pages 464-467
    Published: 2000
    Released: March 27, 2006
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    A 70-year-old man with NIDDM was diagnosed as having renovascular hypertension (RVH), based on a stenosis of the ostial portion of the left renal artery with markedly elevated plasma renin activity (PRA) in both the left renal vein and the peripheral blood, and positive captopril tests. After percutaneous transluminal renal angioplasty (PTRA), his blood pressure (BP) and PRA normalized. However, since restenosis occurred three months later, stent therapy was applied, and consequently BP and PRA normalized immediately after this procedure. During the one-year follow-up, side effects have not been noted. We propose that stent therapy may be feasible for ostial renal artery stenosis in elderly diabetic patients.
    (Internal Medicine 39: 464-467, 2000)
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  • Chung-JUNG WU, Yuh-Min SONG, Wayne Huey-Herng SHEU
    2000 Volume 39 Issue 6 Pages 468-471
    Published: 2000
    Released: March 27, 2006
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    We report a case of tertiary hyperparathyroidism in an X-linked familial hypophosphatemic rickets (XLH) patient under regular calcitriol and self-adjusted large doses of oral phosphate salt (2.4-3.6 g/day in 4-5 divided doses) according to his serum phosphate level. Tertiary hyperparathyroidism is an unusual complication of XLH patients during treatment. As there is growing evidence that a high phosphate diet may induce hyperplasia of the parathyroid glands, it is important to avoid the stimulation of the parathyroid glands by high doses of phosphate administration in XLH patients. Serum calcium, phosphate, alkaline phosphatase, and also parathyroid hormone should be measured regularly in order to facilitate an early diagnosis of secondary hyperparathyroidism during the treatment of XLH patients, since this stage is reversible with calcitriol and reduced doses of phosphate salt.
    (Internal Medicine 39: 468-471, 2000)
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  • Hiroshi NOTO, Tomoaki MITSUHASHI, Shun ISHIBASHI, Satoshi KIMURA
    2000 Volume 39 Issue 6 Pages 472-473
    Published: 2000
    Released: March 27, 2006
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    A 65-year-old man presented with hyperthyroidism associated with thyrotoxic dysphagia. Treatment with thiamazole improved his symptoms promptly. Although dysphagia is a rare manifestation of thyrotoxicosis, it should be emphasized that the possibility of hyperthyroidism must be discussed in unexplained dysphagia because it is readily treatable.
    (Internal Medicine 39: 472-473, 2000)
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  • Michio HAYASHI, Kenmei TAKAICHI, Toshitsugu KARIYA, Hiroki KANBE, Naot ...
    2000 Volume 39 Issue 6 Pages 474-477
    Published: 2000
    Released: March 27, 2006
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    A 76-year-old man with hypoglycemic coma was diagnosed as malignant insulinoma with multiple hepatic metastases. Embolization was done for two-thirds of the hepatic mass and it rapidly lowered the serum immunoreactive insulin. He was discharged without medication and has been free from hypoglycemia. After the embolization, the serum creatine kinase (CK) level increased transiently although there was no evidence of myocardial infarction. On electrophoresis, the CK activity showed an abnormal peak, suggesting mitochondrial CK. CK release after embolization has been reported in only a few cases with endocrine tumors, which might indicate some relationship between active energy metabolism and mitochondrial CK.
    (Internal Medicine 39: 474-477, 2000)
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  • Kanoko SAWAFUJI, Hiroaki OKAMOTO, Akira NAGATOMO, Hiroshi KUNIKANE, Ko ...
    2000 Volume 39 Issue 6 Pages 478-481
    Published: 2000
    Released: March 27, 2006
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    We present a rare case of a five-year survivor of small cell lung cancer with severe complications who responded to combined modality treatment. Prior to initial chemotherapy, he experienced severe complications including sepsis, pneumonia, ileus, and a performance status of 4. He was treated with an ileus tube and IVH, and was managed by mechanical ventilation for four days. After his general condition improved, he received combination chemotherapy of carboplatin, with the target area under the plasma concentration versus the time curve (AUC) of 5 mg • min/ml day 1, and etoposide (80 mg/m2) on days 1, 2, 3 for four courses, and complete remission (CR) was obtained. Six months later, systemic relapse occurred, but he achieved complete remission again with nine courses of CODE (cisplatin, vincristine, adriamycin, and etoposide) chemotherapy and sequential chest radiotherapy. Five years after the initial chemotherapy, the patient is alive and disease free.
    (Internal Medicine 39: 478-481, 2000)
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  • Koji TAKAHASHI, Kenichi KASHIHARA, Katsuji SHINAGAWA, Tadashi YOSHINO, ...
    2000 Volume 39 Issue 6 Pages 482-485
    Published: 2000
    Released: March 27, 2006
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    We report a 22-year-old man who had myositis in the course of chronic graft-versus-host disease after bone marrow transplantation for acute monocytic leukemia. The distribution of muscular involvement was different from idiopathic polymyositis. Muscular atrophy and weakness were noted in the distal muscles as well as in the proximal muscles of the upper extremities but there was little weakness in the proximal muscles of the lower extremities. However, histological and immunohistochemical study of the biceps brachii muscle showed findings similar to those of idiopathic polymyositis. It was suggested that myositis can be a manifestation of chronic GVHD caused by a cellular immune reaction by donor T cells.
    (Internal Medicine 39: 482-485, 2000)
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  • Yasuji SUGIYAMA, Mari HONMA, Teiji YAMAMOTO
    2000 Volume 39 Issue 6 Pages 486-489
    Published: 2000
    Released: March 27, 2006
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    Following a high fever, a healthy woman became comatose within a few days. Severe cerebellar symptoms appeared when she regained consciousness. The brain MRIs revealed abnormal signal intensity of the cerebellar cortex and brainstem gray matter, however, no abnormalities were revealed in the cerebral hemispheres. Acute inflammation due to direct viral or autoimmune involvement of the cerebellar and brainstem gray matter was a likely explanation and thus acute cerebellitis may in fact be a rhombencephalitis. Among the previous reports of acute cerebellar ataxia, this is perhaps one of the most profoundly affected cases and appears important for the understanding of the target of this particular form of encephalitis.
    (Internal Medicine 39: 486-489, 2000)
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  • Masayuki MATSUDA, Jun MIKI, Ken-ichi TABATA, Masaya IKEZOE, Nobuhiro N ...
    2000 Volume 39 Issue 6 Pages 490-494
    Published: 2000
    Released: March 27, 2006
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    A 46-year-old woman showed proteinuria and hematuria after left blepharoptosis, and revealed a histopathology of membranous nephropathy (MN) at renal biopsy. She was diagnosed as having myasthenia gravis (MG) because of a positive edrophonium test and anti-acetylcholine receptor (AchR) antibodies in serum. We found a decrease in anti-AchR antibodies after extended total thymectomy, in parallel with an improvement in both urinary findings and myasthenic symptoms. In this case, MG preceded MN and the thymectomy was effective for both diseases, suggesting that the thymus might play an important role in the pathogenesis of MN.
    (Internal Medicine 39: 490-494, 2000)
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  • Setsuko FUJIWARA, Hiroyuki OSHIKA, Kenzo MOTOKI, Kenji KUBO, Yukiaki R ...
    2000 Volume 39 Issue 6 Pages 495-498
    Published: 2000
    Released: March 27, 2006
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    A 37-year-old woman was admitted in a comatose state, after exhibiting fever and diarrhea. Diabetic ketoacidosis was diagnosed due to an increased blood glucose level (672 mg/dl), metabolic acidosis, and positive urinary ketone bodies. On the fifth hospital day, despite recovery from the critical state of ketoacidosis, the patient suffered from dysphagia, hypesthesia and motor weakness, followed by respiratory failure. Cerebrospinal fluid analysis was suggestive of Guillain-Barré syndrome (GBS). Autonomic dysfunction was manifested as tachycardia and mild hypertension in the acute stage. Marked orthostatic hypotension persisted long after paresis was improved, indicating an atypical clinical course of GBS.
    (Internal Medicine 39: 495-498, 2000)
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  • Satoshi KOYAMA, Kazutoyo MORITA, Syuji YAMAGUCHI, Toshiaki FUJIKANE, N ...
    2000 Volume 39 Issue 6 Pages 499-502
    Published: 2000
    Released: March 27, 2006
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    We present an adult case of mumps brains tern encephalitis. He was successfully treated with steroid pulse therapy and recovered completely except for persistent dysuria. He had not been vaccinated and had no history of acute mumps infection. We consider that encephalitis in this case was caused by a reversible autoimmune process triggered by mumps infection. We emphasize the usefulness of pulse therapy for the treatment of some cases of mumps brainstem encephalitis in addition to the importance of mumps vaccination to prevent such a severe complication as encephalitis.
    (Internal Medicine 39: 499-502, 2000)
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  • Masahiro MORI, Kenji TAKAGI, Satoshi KUWABARA, Takamichi HATTORI, Shig ...
    2000 Volume 39 Issue 6 Pages 503-505
    Published: 2000
    Released: March 27, 2006
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    We describe a patient who developed Guillain-Barré syndrome (GBS) following hand-foot-and-mouth disease (HFMD) which is known to be caused by enterovirus infection. A 35-year-old man developed acute paraparesis and dysesthesia in the four limbs following typical skin eruption of HFMD. Electrophysiologic studies showed peripheral nerve demyelination predominant in the distal terminals. HFMD is a rare cause of meningitis, encephalitis, and polio-like myelitis, but GBS following HFMD has never been described.
    (Internal Medicine 39: 503-505, 2000)
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  • Hiroyuki MORITA, Hisashi DAIDO, Tetsuya SUWA, Tomoatsu MUNE, Koji YOSH ...
    2000 Volume 39 Issue 6 Pages 506-511
    Published: 2000
    Released: March 27, 2006
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    A 51-year-old woman with overt congestive heart failure with pleural and pericardial effusion was treated with furosemide and nifedipine, leading to improvement in her condition and a decrease in effusions. An echocardiography demonstrated mitral and aortic regurgitation with mitral valve prolapse, which caused the congestive heart failure. Since leukocytopenia and lymphocytopenia with arthralgia could be observed, serological investigations were performed. She was diagnosed as having systemic lupus erythematosus (SLE) with antiphospholipid syndrome, and started, on a treatment of prednisolone and aspirin. Based on the treatment, the pleural and pericardial effusion went into complete remission, indicating that the serositis related to SLE had overlapped the heart failure. Since there was no evidence of any other diseases that could be responsible for the valvular lesions, we concluded that they were due to antiphospholipid syndrome. The administration of prednisolone had no significant effect on valvular morphology or function as demonstrated by echocardiography. When patients with valvular disease are seen, a valvulopathy related to antiphospholipid syndrome should be considered as part of the differential diagnosis.
    (Internal Medicine 39: 506-511, 2000)
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  • Yuko MATSUDA, Masayoshi HARIGAI, Hiroshi NAKAJIMA, Hisae TERAJIMA, Toh ...
    2000 Volume 39 Issue 6 Pages 512-516
    Published: 2000
    Released: March 27, 2006
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    A 60-year-old woman was admitted to our hospital with complaints of muscle weakness and erythema on her extremities. Gottron's sign, heliotrope rash, elevation of serum myogenic enzymes, electromyography and magnetic resonance imaging findings established a diagnosis of dermatomyositis (DM). She was treated with 60 mg of daily prednisolone. One week later, she suddenly developed splenic and renal infarctions, which were considered to have resulted from vasculopathy associated with DM. Cyclophosphamide and anticoagulants along with increasing the dosage of corticosteroid were effective. This is the first report describing splenic and renal infarctions in a patient with adult-onset DM.
    (Internal Medicine 39: 512-516, 2000)
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  • Teruko NAKAMOTO, Masahide YOSHIKAWA, Toshiya NAKATANI, Yoshiko YAMANE, ...
    2000 Volume 39 Issue 6 Pages 517-521
    Published: 2000
    Released: March 27, 2006
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    In microscopic polyangiitis (MPA), renal manifestations are very common as first symptoms. Here, we report a case of MPA which presented liver dysfunction prior to noted renal manifestations. A 58-year-old woman was hospitalized because of a fever for 8 weeks. A laboratory examination revealed marked elevation of alkaline phosphatase and γ-glutamyl transpeptidase, while blood urea nitrogen and creatinine levels remained normal. Although apparent renal dysfunction developed in this case soon after hospitalization, physicians should be aware of the variety of clinical manifestations in MPA. Moreover, antineutrophil cytoplasmic autoantibodies were found to be helpful for diagnosing MPA.
    (Internal Medicine 39: 517-521, 2000)
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