Neurologic Complications Associated with Influenza Vaccination: Two Adult Cases

Naoko NAKAMURA; Kazuya NOKURA; Takaaki ZETTSU; Hiroshi KOGA; Masayuki TACHI; Masaki TERADA; Hideshi KATOH; Yuri ITOH; Hiroyuki OSAWA; Toshihiko OZEKI; Hiroko YAMAMOTO

doi:10.2169/internalmedicine.42.191

Naoko NAKAMURA, Kazuya NOKURA, Takaaki ZETTSU, Hiroshi KOGA, Masayuki TACHI, Masaki TERADA, Hideshi KATOH, Yuri ITOH, Hiroyuki OSAWA, Toshihiko OZEKI, Hiroko YAMAMOTO

Author information

Naoko NAKAMURA
Department of Neurology, Fujita Health University, School of Medicine
Kazuya NOKURA
Department of Neurology, Fujita Health University, School of Medicine
Takaaki ZETTSU
Department of Neurology, Fujita Health University, School of Medicine
Hiroshi KOGA
Department of Neurology, Fujita Health University, School of Medicine
Masayuki TACHI
Department of Neurology, Fujita Health University, School of Medicine
Masaki TERADA
Department of Neurology, Fujita Health University, School of Medicine
Hideshi KATOH
Department of Neurology, Fujita Health University, School of Medicine
Yuri ITOH
Department of Neurology, Fujita Health University, School of Medicine
Hiroyuki OSAWA
Department of Neurology, Fujita Health University, School of Medicine
Toshihiko OZEKI
Department of Neurology, Fujita Health University, School of Medicine
Hiroko YAMAMOTO
Department of Neurology, Fujita Health University, School of Medicine

Keywords: acute disseminated encephalomyelitis, myelitis, acute motor axonal neuropathy, influenza vaccination, adult onset, side effect

JOURNAL FREE ACCESS

2003 Volume 42 Issue 2 Pages 191-194

DOI https://doi.org/10.2169/internalmedicine.42.191

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Abstract

We describe two adult cases of neurologic complications occurring after influenza vaccination. The first case was a 62-year-old man who experienced convulsions 5 days after vaccination, and the second case was a 70-year-old man who exhibited paraplegia 7 days after vaccination. Diagnoses of acute disseminated encephalomyelitis and transverse myelitis with acute motor axonal neuropathy were made, respectively, and steroid pulse therapy and intravenous gamma globulin therapy alleviated the patients' symptoms. Although the efficacy and cost benefit of influenza vaccination have been widely accepted, such neurologic complications might occur in the elderly or even in adults.
(Internal Medicine 42: 191-194, 2003)

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