Journal of Information Processing
Online ISSN : 1882-6652
ISSN-L : 1882-6652
Towards Privacy-preserving Authenticated Disease Risk Queries
Nusrat Jahan MozumderMaitraye DasTanzima HashemSharmin AfroseKhandakar Ashrafi Akbar
ジャーナル フリー

2019 年 27 巻 p. 624-642


Recent improvement in genomic research is paving the way towards significant progress in diagnosis and treatment of diseases. A disease risk query returns the probability of a patient to develop a particular disease based on her genomic and clinical data. Despite various innovative prospects, frequent and ubiquitous usage of genomic data in medical tests and personalized medicine may cause various privacy threats like genetic discrimination, exposure of susceptibility to diseases, and revelation of genomic data of relatives. Another major concern is on ensuring the reliability of the genome data and the correctness of the computed disease risk, which is known as authentication. We develop a novel secret sharing approach to protect privacy of sensitive genomic and clinical data, disease markers, disease name, and the query answer while ensuring authenticated result of the disease risk query. In addition, we discuss the applicability of our approach in the field of personalized medicine. We perform a comprehensive security analysis for our system. Experiments with real datasets show that our approach for authenticated disease risk queries achieves a high level of privacy with reduced processing and storage overhead.

© 2019 by the Information Processing Society of Japan
前の記事 次の記事