Abstract
Total exstirpation of pancreas was performed on experimental animals, fully grown dogs, and the livers were examined. For the staining of fat and glycogen, Sudan III test and Schiff's test were used, respectively. The fluctuation of fat and glycogen, comparison of effects of insulin, kallikrein, methionine, glucuronacid, dehydrochrolacid, vitamin B12 were studied.
Results are as follows;
1) Development of fatty liver was seen by 1-7 days after exstirpation of pancreas, generally (70%). Hepatic glycogen decreased remarkably in the first 24 hours. Number of days after exstirpation and the degrees of fat accumulation were not in any relations.
2) In all cases, that survived 4-5 days after insulin injection, development of fatty liver was found. However, the degree of fatty liver was slight and hepatic glycogen was little. By the injection of kallikrein, increase of hepatic glycogen was observed.
3) Injection of methionine, glucuronacid and dehydrocholacid prevented fatty liver and increased the amount of hepatic glycogen remarkably.
4) Injection of vitamin B12 prevented the development of fatty liver very slightly, and it increased the hepatic glycogen.
