Total exstirpation of pancreas was performed on experimental animals, fully grown dogs, and the livers were examined. For the staining of fat and glycogen, Sudan III test and Schiff's test were used, respectively. The fluctuation of fat and glycogen, comparison of effects of insulin, kallikrein, methionine, glucuronacid, dehydrochrolacid, vitamin B₁₂ were studied.
Results are as follows;
1) Development of fatty liver was seen by 1-7 days after exstirpation of pancreas, generally (70%). Hepatic glycogen decreased remarkably in the first 24 hours. Number of days after exstirpation and the degrees of fat accumulation were not in any relations.
2) In all cases, that survived 4-5 days after insulin injection, development of fatty liver was found. However, the degree of fatty liver was slight and hepatic glycogen was little. By the injection of kallikrein, increase of hepatic glycogen was observed.
3) Injection of methionine, glucuronacid and dehydrocholacid prevented fatty liver and increased the amount of hepatic glycogen remarkably.
4) Injection of vitamin B₁₂ prevented the development of fatty liver very slightly, and it increased the hepatic glycogen.

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By means of the myocardium phosphatide precipitation reaction (ACPR) Araki has previously reported that myocardium phosphatide increased in sera at easily infections condition and after motor exercises. The author has examined the reaction on workers, employee of the hospital and on patients in the hospital, of various diseases.
Factory workers, under 20 years of ages and over 36 years of ages, gave changes in their titer of ACPR, conducted before their work and after the work. The average titer of ACPR was comparatively low among the workers employed more than 10 years ago. Meanwhile workers employed less than 1 year ago showed high titer.
Those workers who have hereditary heart diseases or who have anamnesis of focus infections, allergic diseases or hook-worm disease, showed the tendency of increase of titer after work.
The average titer of serum ACPR of healthy person was 1:800 and the average titer of euglobulin ACPR of healthy person was 1:48.
Patients, who have heart disease, tuberculosis, tonsillitis, beri-beri, bronchial asthma, hepatitis, urticaria, typhoid fever, nephritis, hook-worm disease, uterine myoma, showed high titer of ACPR.
Patients with myocardial damages identified by ECG showed high titer of ACPR-patients with cancer of digestive organs, liver cirrhosis or hypoproteanemia showed low titer.
For the diagnosis of myocardial damages, the euglobulin ACPR was more sensitive than the serum ACPR test, although, there was a parallel corelation between both tests.
The decrease of albumin/globulin ratio, especially the increase of gumma globulin tend to increase the titer of ACPR.
Adrenalin had the tendency of increasing the ACPR titer, while atropin and TEAB had no effects upon it.

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Serum-reaction of syphilis (Wasserman's reaction) showed positive in cases which received the implantation of endocrine organ.
141 in 171 cases (82.4%) were affected. The negative 30 cases might be passed over, so that the whole cases might be temporally affected.
They were affected after 1-2-3 weeks after the first implantation, or after 1-2 times of implantation.
However, the affection differed from the true Wasserman's reaction in the point, that haemolytic reaction were disturbed even in the control test-tube containing no antigen.

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The author has conducted theoretical study on the advantages and disadvantages of high voltage tomography.
The high voltage tomography can decrease the geometrical unsharpness by means of the use of micro-focus tube, increasing the efficiency of blurring the images of the objects outside the focused section, and can lessen the angle of rotation of the tube.
Disadvantages of this technique are that it increases the scattered rays and reduces the contrast. However, some devices will, in future, eliminate the scattered rays as much as possible and this technique should be used with better results.

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Observation was conducted upon the course of sputa culture, taken once a week for 6-12 months, from the 445 patients in 23 national sanatoria, Japan. The patients were those who gave slightly positive tubercle bacilli in sputa culture at recovering stage and had been charged with walking and occupation. The observation was made from February 1953 to January 1954.
1) Out of 189 cases under occupational therapy and 94 discharged cases, 59 cases were under occupation, engaging in works for more than 8 hours per day. Number of non-occupation was 27 cases.
2) 39 cases (13.8%) became worse, 35 cases were still in sanatoria, among them 2 cases were fatal (by surgical operation). Degeneration was found by x-ray in 24 cases, of which 11 cases had newly formed cavities. 27 cases had increase in the amount of excreted positive bacilli, 3 cases had blood-vomitting, 1 case had pulmonary perforation by composite resin stuffing balls.
3) When a case had more than 100 colonies, in the maximum, of excreted positive bacilli, degeneration percentage was very high.
4) When frequency of excreted bacilli was over 10-20%, the degeneration percentage was high at statistically significant level. Among the patients, who had not bacilli for 6 months to 1 year, degeneration was found, however, they recovered easily by chemotherapy.
5) There was no significant difference between percentage of degeneration and that of therapeutics.
6) After the occupational therapy for more than 6 months, degenerated cases were observed in considerable number. (32.4% of all the degenerated cases).
7) In non-degeneration cases, no changes in the amount of bacilli were seen in continuous sputa culture throughtout one year. In such non-degeneration cases, charge of occupation did not give any influence upon the increase or decrease of excretion of bacilli.
8) In the results of chemotherapy for 57 cases in slightly positive cases, 40 cases (70.2% became negative through the chemotherapy, but when the treatment was discontinued, half of them became positive by 15th week, and 70.8% became positive by 30th week. INAH seemed to be more effective than the other drugs in the treatment of slightly positive cases.
9) Slightly positive cases were generally those who had some problems in their treatment, even through pulmonary resection or collapse therapies. Satisfactory therapy is desirable prior to the order of occupation therapy, and time, methods, and courses should be regarded carefully at the start of occupation-therapy.

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In 4 of 76 TB cases autopsied recently in our sanatorium, amyloid degeneration, which is regarded as very rare occurrence in Japan, was found in spleen. It is well known fact that the tuberculosis in Japan tends to lose its characteristics and takes European type tuberculosis. However, it may be said, from the literature, that amyloid degeneration has the tendency of increase in these years.
After detailed histological studies on 4 cases, some interesting findings, which are rare in our country, were obtained, and the author investigated the pathogenesis.
In case I and case II, the amyloid lesions showed the typical sago spleen type. In case III, the slight deposition of amyloid with concomitant miliary tubercles were found around the blood vessels and in the follicles. In case IV, the lesions were found in the walls of vessels and their surrouuding tissues only. In one case (case II), degeneration lesions in the spleen were abundant and the kidney and lymphnodes were also involved with amyloid, while in another cases amyloid were found only in the spleens.
Hypertrophied reticulum cells and elastic fibers, which indicated the previous structure of capillaries were frequently observed in amyloid degeneration lesions. The slight amyloid degeneration seems to begin at the periphery or in the central part of the follicles and around the elipsoids in the pulps, with proliferation of reticulum cells. These locations of amyloid degeneration agree with that of the tubercles in spleen. It is quite likely that the amyloid deposition has close connection with reticulum cells. Tubercle bacilli in the amyloid lesions were found in all the 4 cases. Giant cells of Langhans's type and bleedings were seen in some cases.
Thus some resemblances in histological findings between amyloid and tubercle in spleen, i. e., sites of focus lesions, presence of tubercle bacilli, erythrocytes and giant cells and close relation with reticulum cells, can be pointed out. The author believes that amyloid in tuberculosis patients is the result of the antigen-antibody reaction in which the tubercle bacilli act as antigen. Accordingly, it can be said that the striking rarity of amyloid degeneration in Japan has been nothing but an appearance of TB type in Japan.
It is conceivable that chemotherapeutics have a influence on the development of amyloid degeneration, but it is not clear enough whether the recent increase of amyloid degeneration instances depends only upon the administration of chemotherapeutics.

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Many reports have been published on EKG taken before and after operation of collapse therapy, i. e., thoracoplasty in pulmonary tuberculosis. However, only one report was published on the EKG during operation. The authors studied EKG during operation. Standard limb leads were used.
Results are as follows;
1) 6 cases out of 10 cases showed vertical inclination and the other 2 cases showed horizontal inclination. Another 2 cases showed no remarkable changes. 3 cases, examined at sitting posture after operation (artificial pneumoperitoneum), showed vertical inclination.
2) 10 out of the 18 cases, that received artificial pneumothorax on the right side, showed. vertical inclination during the operation. Meanwhile, 7 out of 16 cases, that received pneumothorax on the left side, showed horizontal inclination during operation. The degree of the shift were remarkable when pleural adhesions were present.
3) During operation of the temporary collapse therapy, changes of P-wage were not recognized, generally. Sometimes, when pleural adhesions or other complications were present, slight changes of ST-T were observed.
4) During operation of open pneumolysis, EKG changed in the electrocardiographic position.
5) Electrocardiographic changes during operations of temporary collapse therapy were chiefly that of the position of heart.

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The pulseless disease, which has been known as the Takayasu's disease, is characterized, according to the nominator, Shimizu and Sano, for the trias:
1) Absence of the pulse at the wrist,
2) Vascular changes in the eye grounds,
3) increased carotid sinus reflexes.
The author reports a peculiar case of this disease, which showed additionally the absence of the pulse at the legs.
The patient is a wife of 26 years old, and has been suffering from this disease these 4 years old.
Her main complaints are adynamia of the extremities, diziness, palpitation, nausea, vomitting etc.
Absence of the pulse is cbserved at radialis, ulnaris, brachialis arteries at the both arms, and dorsalis pedis, poplitea arteries at the both legs.
A. carotis and femoralis are palpable.
Carotid sinus reflexes are increased and showed vagotonic type. The arteriography of a femoralis showed the obturation in it, and anastomosis-formation.
Though the vascular changes of the eye ground is impossible to examine for the corneal turbidity (Ceratitis superficialis tbc), the above findings may be adequate to determine a case of the pulseless disease.
Furthemore this patient had complications of tuberculous disease, such as Ceratitis superficialis tbc, lymphadenitis axillaris tbc, erythema nodosum and anamnesis of peritonitis chronica.
These facts must have some relation to the pathogenesis of this disease.

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