放射性金¹⁹⁸Auによる悪性腫瘍の治療

抄録

Radioactive isotope treatment for malignant neoplasmas has been achieving a remarkable progress, particularly in it's internal use. Radioactive phosphor (Cr³²PO₄) was used for a time, then radioactive colloidal gold (Au¹⁹⁸) took it's place.
Treatment of pleuritis and peritonitis carcinomatosa with the radioactive colloidal gold shows satisfactory result. Since September 1955 the author utilized gold manufactured by the Radio-Chemical Center, England.
Mice with ascites tumor (Ehrlich) were tested with this. Change of tumor cells, pathological reaction of cancer cells and survival period of the diseased animals were tested and these indicated fairly satisfactory therapeutic effect with less secondary reaction than Cr³²PO₄.
Then Au¹⁹⁸ was applied clinically to human bodies resulting in far superior effect to the radioactive phosphor (Cr³²PO₄).
85 patients with malignant neoplasma were observed in a few months; intra peritoneal injection-43 cases, intra pleural injection-19 cases and other procedure-23 cases.
1) At the 7th days diiferent doses of Au¹⁹⁸ were intraperitoneally injected to mice with ascites tumor. Injection of 1mc manifested the most prominent result.
Described formula indicates absorbed and effective roentgen dose (rad). Assuming volume of ascites of a mouse as of 10cc, the rad will be 100μc/g/tissue.
2) Ascites dropsy of the mouse was stopped by giving injection only once ; simultaneously, prolonged survival effect was cinsiderable.
3) Several injections a month apart is considered adequate.
4) 62 cases were injected intra pleuro-peritoneousily. 19 cases out of 62 lived more than 6 months while 11 cases survived more than a year.
5) One necessary therapeutic dose is 30 to 100mc, Over dosage radiation should be strictly avoided since it causes peritoneal effusions resulting in ileus. Maximum dosage is estimated as 80mc.
6) Au¹⁹⁸ brings humans a ray of hope recovery from carcinomatous pleuro-peritonitis. A complete cure is expectative, if Au¹⁹⁸ is applied at the early stage before the malignant tumor cells form a big tumor. The longest clinical arrest I have experienced was 3 years and 2 months.