Abstract
Cases progressive lepromatous leprosy were admin istered 44' diethoxy diphenyl thiourea (provisionally called as Ethoxy TC), pp'dichloro diphenyl thiourea (Provisionally called as Chlor TC) and 4 butoxy 4' dimethyl amino diphenyl thiourea (Chiba 1906) in order to observe the therapeutic effects and side effects as well as the recurrence rate.
Method
The method of administration was Ethoxy TC and TC and Chlor TC were administered in a daily dose of 0.6-1.5g and Chiba 1906 in a dose of 1.5-3.0g. The treatment with Ethoxy TC was given to 3 patients for a period of 8-18 months and Chiba 1906 to 17 patients for 6 -10 months, The administration of Chlor TC was discontinued by the end of 3 weeks due to the development of side effects.
Results
Both Ethoxy TC and Chiba 1906 gave practically no side effects and immediately after starting treatment, showed considerable therapeutic effect. But recurrences began to appear 6 months after treatment was discontinued. Two of the 3 cases receiving treatment with Ethoxy TC and 7 cases out of the 17 cases receiving Chiba 1906 showed recurrence.
Conclusion
It was concluded, in view of the findings stated above, the above said drugs should be used in combination with some other drugs rather than alone. Chlor TC was found to be inadequate for the treatment due to its side effects of anemia and the disturbance of hepatic functions.
