Abstract
From January 1955 to July 1960 the relationship between anti-tuberculous drugs and resistant organisms was studied in 1, 746 patients with pulmonary tuberculosis who were admitted to Osaka-fukusen Sanatorium.
The patients from whom were cultured tubercle bacilli which were resistant to one or several drugs were 53.5% for all tested persons.
The rate of resistance of tubercle bacilli to antituberculous drugs at the time of entering the hospital did not show a continuous increase year after year.
Regarding untreated patients during January 1959 and July 1960, the streptomycin-and isoniazid-resistant strains were found in 6.8% while with treated patiens in 64.7%.
Even though patients had resistant strains at the time of admission, in cases of type B, according to Gakken's classification, therapy over six months showed a conversion rate of 53% of bacilli in sputa, and those of type C a conversion rate of 27.1%.
