In measuring the retinal artery pressure, the following four items should be stressed.
1. Fluctuation in systemic blood pressure may be obsrved during measurement of the retinal artery prssure.
In correlating the systemic to the retinal artery pressure, values for systemic blood pressure should be compared with the retinal artery pressure measured simultaneously.
2. The difference in fluctuation of the systemic blood pressure during measurement of the retinal artery pressure was observed to be significant between the 3 groups of hypertensive patients. A-group: hypertensive patients with increased retinal artery pressure; B-grroup: well balanced hypertensive patients; C-group: hypertensive patients with decreased retinal artery pressure.
3. Difference in values of the retinal artery pressure may be observed for the varies of instrument used.
The type of instrument and the method of measurement was observed to exert some influence on the variations in the systemic blood pressure.
4. In measuring the retinal artery pressure, special attention should be given to the limitations of instrument employed.

View full abstract

In part 1, Hypertensive patients were divided into 3 groups A, B, and C, according to the relation between the retinal artery pressure and the systemic blood pressure.
It is generally accepted that the ratio of the retinal to the systemic blood pressure is about 50%. This ratio, however, should be corrected in regards to the subject or factors involved in the measurement of the systemic blood pressure.
In group B, when subjects with the systemic blood pressure range 150 to 180 mm of mercury, the ratio of the retinal to the systemic is found almost to be 50%.
However, the systemic pressure of under 150mm changes the ratio higher than 50%, while with pressure over 200mm of mercury the ratio proves to be lower than 50%.

View full abstract

The author studied the capillary configration and ballistocardiogram of pregnant women during pregnancy and after their delivery, who were presumed to undergo changes of haemodynamics in a relatively short period of time.
Materials and Method
1. 20 normal pregnant women were examined by the above mentioned items at the three different periods; in the latter term of the pregnancy, immediately after the perturition and 2-6 months after the childbirth.
2. The examination of the capillaries were performed at room temperature 15°C-25°C. Cedar oil was dropped on the cuticle of the left and right digitic annulares which were placed on the same level with the heart. A Columbia cutanaeous phtotographic microscope. with 5x ocular and 11x odjective, was used.
Regarding the capillaries the following items were examined; the width of the arterial limbs, the width of the venous limbs, width of the loop, length of the arterial limbs, the number of visible capillaries, the number of windings, etc. Regarding the state of bloodstream the following items were examined; the continuity of the blood-stream, the degree of the fullness, the presence or absence of granules, and the velocity. Furthermore, the subpapillary venous plexus was examined and measured with the aid of micrometer (μ). A low frequency table ballistocardiograph was applied and the ballistocardiogram was obtained and it was analysed.
Results
No morphological abnormalities was noticed in the capillary configuration of the normal pregnant women. However, the blood-stream was characterized by the discontinuations, granular appearance, lack of fullness and slow velocity during the pregnancy. After the delivery day by day these phenomena tended to changes as to the continuity, absence of granules, favorable fullness and fast velocity.
In the ballistocardiograms, L-wave increased in the latter period of the pregnancy which decreased day by day after the childbirth.

View full abstract

Investigation was made on anemia in leprosy, especially its relationship with the antileprosy drugs.
1. In comparison with healthy individuals, leprosy patients without any treatment show slightly lower erythrocyte count and hemoglobin content, however no change is seen among hemoglobin index. Anemia is observed more frequently on lepromatous type patients than tuberculoid type patients.
2. With the administration of antileprosy drugs among the leprosy patients anemia (diminishing of erythrocyte count less than 500, 000 or hemoglobin content less than 10%) appears in 33-60% by Promin or DDS and in 8% by Ciba 1906. The erythrocyte count is 1, 000, 000 in average and that of the hemoglobin content is around 18%.
3. Except a fairly high rate of the appearance of anemia followed the administration of Promin and DDS, no remarkable difference was observed among other cases treated by the antileprosy drugs such as Promizol, Diazon, Ciba 1906 and Taifumin.
4. The number of Promin injections has almost no relation to the frequency of the appearance of anemia, but in the cases that the injections were repeated more than 1, 600 times during the period of 10 years, there was a slight elevation in the frequency. Dose of a single injection or sex of the cases have no influence on the frequency of appearance of anemia.
5. Anemia caused by the sulfone drugs administration is considered to be due to the lowering of the bone marrow functions.
6. Anemia of leprosy is alleviated by the use of antileprosy drugs.
7. Liver preparations and vitamin B₁₂ are effective for the treatment of the anemia caused by the administration of antileprosy drugs.

View full abstract

From January 1955 to July 1960 the relationship between anti-tuberculous drugs and resistant organisms was studied in 1, 746 patients with pulmonary tuberculosis who were admitted to Osaka-fukusen Sanatorium.
The patients from whom were cultured tubercle bacilli which were resistant to one or several drugs were 53.5% for all tested persons.
The rate of resistance of tubercle bacilli to antituberculous drugs at the time of entering the hospital did not show a continuous increase year after year.
Regarding untreated patients during January 1959 and July 1960, the streptomycin-and isoniazid-resistant strains were found in 6.8% while with treated patiens in 64.7%.
Even though patients had resistant strains at the time of admission, in cases of type B, according to Gakken's classification, therapy over six months showed a conversion rate of 53% of bacilli in sputa, and those of type C a conversion rate of 27.1%.

View full abstract

Investigations were made of the relationship between the recurrence of lepromatous leprosy and the method of treatment, particularly, 1) whether or not this recurrence occured due to insufficient administration of antilepsory drugs, 2) from the rate of development of recurrence which drug was most effective, and also 3) in order to prevent recurrence what
was the minimum total annual dose of the drugs.
Results
1. The recurrence rate was 5-13%, and there was no appreciable differences between the patient groups treated either single with Promin, Promizol, DHDS, Diazone or with combinations of Promin and Promizol, Promin and Diazon.
2. With either Promin or Promizol, the recurrence rate was lower among the patients who receved a larger numder of injections and larger total amount of the drug per year.
From the standpoint of recurrence the minimum number of Promin injections required was 160 times per a year and the minimum total amount of Promizol was 600g.
3. 20% of the patients with recurrences received more than minimum amount of the drugs, while rest of them were found to be due to insufficient treatment. Some of the former case recurrences might have been caused by the appearance of resistant strains.
4. At 6-7 years after starting treatment the rate of recurrrence was found to be the highest; 14.6% with Promin and 28.6% with Promizol. The following high rate of recurrence was seen at 8-9 years after starting treatment.
5. The rate of recurrence in patients who suspended Promin treatment was 41.9%. As to the time of recurrence, within 1 year 80% and within 2 years 55.2%. Most cases of recurrence occured within a short period after suspending treatment.
This was considered due to insufffcient treatment. Therefore, studies should be to determine methods to eliminate or reduce complications or side effects associated with administration of antileprosy drugs, so that we shall be able to give adequate antileprosy treatment to prevent the development of recurrences.
From the patients who received sufficient treatment no cases of recurrence was observed.

View full abstract