鳩致死量による各種Digitalis剤の毒性比較

抄録

Previously using frogs, cats, etc, their lethal doses have been measured for the biological assay of digitalis. Recently pigeons are generally used for them. Measuring lethal doses in pigeons to some known digitalis preparations such as digitoxin, lanatoside c,
g-strophanthin, Asystin, 3-acetyl strophanthidin, and 16-acetyl digitalinum verum (a newly produced cardiac glycoside) were examined as to potency, the rate of onset and disappearance of action and the rate of the absorption from the gastrointestinal tract.
Method:
1. In most cases etherized pigeons were used.
2. Intravenously small amounts of digitalis preparations were injected at every 2.5min, 5min., 10min, or 20min, till the animal died of cardioplegia, and thereby the potency and the rates of onset and disappearance of the drug was observed.
3. Three to 24 hours after the intravenous administration of a half of 10min, lethal dose which was determined at the above experiments, then the same drug was injected intravenously at intervals of 10min, till the animals death and thereby the detoxification grade was observed in each preparation.
4. Three hours after administration of a half of 10min, lethal dose which was determined in the first experiment, then the same drug was injected intravenously every 10min. till death. Lethal doses were determined by the oral administration only.
In these ways the absorption rate from the gastrointestinal tract was observed in each preparation.
Results:
1. Digitoxin: The rates of onset and disappearance of the action were the slowest of the drugs examined, The absorption from the gastrointestinal tract was remarkably easy.
2. Lanatosid C: The rates of onset and disappearance of action were slowest except for digitoxin. However, absorption was not easy.
3. Asystin: The rate of onset of action was fast but the disappearance is not so slow.