抄録
The report is presented of an incidence of primary drug resistance (PDR) in tuberculosis within Hokkaido district. (This study was performed in co-operation with 23 hospitals and sanatoriums.)
A total of 1, 459 strains isolated from an almost equivalent number of patients previously untreated were examined on their drug-susceptibility, in which constituted with 10γ per ml. of SM, 1.0γ per ml. of PAS and INH as the standard concentration of medium respectively.
During the seven-year period from 1957 to 1963, the frequency of PDR was indicated as 15.3% (223 within 1, 459 patients) and the annually observed incidence seemed to be constant since 1959.
These PDR was unaffected by sex.
The incidence of mycobacterial resistance to SM was the highest, but simultaneous resistance to more than one of the three major antituberculosis drugs was observed infrequently.
It was significantly shown by means of cultures of sputa and x-ray findings that the therapeutic responses to major drugs of the complete resistance group revealed on above drug-susceptibility test was remarkably lower than that of incomplete resistance or sensitive one.
On the other hand, 7 nurses and co-workers had some degree of the PDR. Their prognoses, however, did not always be satisfactory.
At this point, physicians, nurses and co-workers have to be more carefully checked epidemiologically.
