抄録
During the period of 9 months, from Sept. 1, 1964 to May 31, 1985, 200 patients were admitted into Sapporo National Hospital and received blood transfusions. The subjects of this review were 98 patients who had been kept under observation more than 3 months after the blood transfusion. Examination mainly consisted of measurement of SCOT and SGPT every 4 weeks.
We assumed that an incubation period would be important in the diagnosis of serum hepatitis. Based on increasings, as well as their processes of alterations, of SGPT, BSP retention and icteric index, the risings of SGPT would be judged as the result of hepatocellular damage.
As the differentials so-called toxic hepatitis must be considered. This would be differentiated by laboratory test such as serum alkaline phosphatase, total cholesterol and eosinophilia, or history of administration of particular drugs prior to the onset.
The diagnosis of serum hepatitis was made, based on laboratory data, subjective symptoms or histological study by liver biopsy.
Results:
1. 28 cases of 98 patients, who received the blood transfusion, had serum hepatitis.
2. The incidence of the hepatitis was 28.6% in patients who received the blood collected at Sapporo District, while 62.59% in patients who received blood sent from Tokyo or Yokohama.
3. No linear correlation exists between the amount of transfused blood and the incidence of serum hepatitis, Frequent transfusions seemed to increase the incidence of serum hepatitis.
4. Duration of incubation was 8-9 weeks in the majority of cases, ranging from 9 days to 18 weeks in 25 cases.
5. Icteric type in the post transfusion hepatitis patients was 25%.
