抄録
This 6-year-old boy was admitted to Hirosaki National Hospital because of acetonemic vomiting. He developed urticaria-like rash, gangrenous angina and lymphadenopathy of the cervical lymph nodes on the 10th day of the hospitalization, when he had high fever for the first time. The high fever dropped down once by administrating various kinds of antibiotics and Dexamethasone, but he had high fever again with rash, hepato-splenomegaly and jaundice after a non-febrile period of one week, when the second high fever elevated, the diagnosis of agranulocytosis was made by C. B. C. and bone-marrow puncture. As for the treatment, Dexamethasone, ACTH, transfusion of fresh blocd, Colistine, Trichomycin, folic acid and VB12 were used after discontinuing antibiotics which had been previously used. He completely recovered with about 2 weeks treatment.
The etiologic studies—provokation test, Prausnitz-Küstner reaction, etc.— in this case revealed that Aminobenzyl Penicillin might be the etiologic agent. We ascertained that antigen-antibody reaction played the role in the etiologic mechanism of the disease.
