小児期肝障害のプロトポルフイリン・ナトリウムによる治療について
1969 年 23 巻 4 号 p. 502-509
詳細
1969 年 23 巻 4 号 p. 502-509
Clinical and experimental effect of Protoporphylin-Natrium (PPN) on liver diseases were discussed:
1) 11 cases of acute hepatitis, 4 cases of serum hepatitis and 2 cases of liver cirrhosis were treated by PPN (0.6-1.0mg/kg/day for 30-180 days). All of these cases were below the age of 13. Icteric index returned to normal within 1-2 weeks in acute hepatitis, 2-3 weeks in serum hepatitis and 8-15 weeks in liver cirrhosis respectively. S-GOT and S-GPT level tended to decrease to normal value within 3 weeks in acute hepatitis, 3-4 weeks in serum hepatitis and 19-26 weeks in liver cirrhosis, Other laboratory data including total protein, total cholesterol and alkaline phosphatase level in serum revealed indefinite results.
2) By administration of PPN (0.6-1.0mg/kg/day for 8-29 days) to 10 cases of neonatal hyperbilirubinemia, serum bilirubin level decreased to normal within 3-6 days.
3) In the cases of rabbit which was treated by ligation of the common bile duct previously, PPN was found to protect liver damage remarkably.
